Origin of Homochirality of Amino Acids in the Biosphere
AbstractDiscussions are made concerning realistic mechanisms for the origin of L-amino acids in the biosphere. As the most plausible mechanism, it is proposed that a mixture of racemic amino acids in the prebiotic sea caused spontaneous and effective optical resolution through self crystallization, even if asymmetric synthesis of a single amino acid has never occurred without the aid of an optically active molecule. This hypothesis is based on recrystallization of a mixture of D,L-amino acids in the presence of excess of D,L-asparagine (Asn). The enantiomeric excess (ee) of each amino acid in the resulting crystals indicates that crystallization of co-existing amino acids with the configuration same as that of Asn took place, although it was incidental whether the enrichment occurred in L- or D-amino acids. In addition, the resulting ee was sufficiently high (up to 100%) to account for the predominance of L-amino acids on the earth.
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Kojo, S. Origin of Homochirality of Amino Acids in the Biosphere. Symmetry 2010, 2, 1022-1032.
Kojo S. Origin of Homochirality of Amino Acids in the Biosphere. Symmetry. 2010; 2(2):1022-1032.Chicago/Turabian Style
Kojo, Shosuke. 2010. "Origin of Homochirality of Amino Acids in the Biosphere." Symmetry 2, no. 2: 1022-1032.