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Chiral Symmetry Breaking Phenomenon Caused by a Phase Transition
Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan
* Author to whom correspondence should be addressed.
Received: 30 December 2009; in revised form: 9 February 2010 / Accepted: 15 February 2010 / Published: 17 February 2010
Abstract: We report the mechanism and scope of “preferential enrichment”, which is an unusual symmetry-breaking enantiomeric resolution phenomenon that is initiated by the solvent-assisted solid-to-solid transformation of a metastable polymorphic form into a thermodynamically stable one during crystallization from the supersaturated solution of certain kinds of racemic mixed crystals (i.e., solid solutions or pseudoracemates) composed of two enantiomers. The mechanism can well be interpreted in terms of a symmetrybreaking complexity phenomenon involving multistage processes that affect each other.
Keywords: preferential enrichment; enantiomeric resolution; optical resolution; chiral separation; polymorphic transition; epitaxial transition; mixed crystal
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Tamura, R.; Iwama, S.; Takahashi, H. Chiral Symmetry Breaking Phenomenon Caused by a Phase Transition. Symmetry 2010, 2, 112-135.
Tamura R, Iwama S, Takahashi H. Chiral Symmetry Breaking Phenomenon Caused by a Phase Transition. Symmetry. 2010; 2(1):112-135.
Tamura, Rui; Iwama, Sekai; Takahashi, Hiroki. 2010. "Chiral Symmetry Breaking Phenomenon Caused by a Phase Transition." Symmetry 2, no. 1: 112-135.