Next Article in Journal
Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function
Previous Article in Journal / Special Issue
Epitope Specificity of Anti-Citrullinated Protein Antibodies
Article Menu

Export Article

Open AccessArticle
Antibodies 2017, 6(2), 6; doi:10.3390/antib6020006

Collagen Autoantibodies and Their Relationship to CCP Antibodies and Rheumatoid Factor in the Progression of Early Rheumatoid Arthritis

1
Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3800, Australia
2
Rheumatology Unit, Royal Melbourne Hospital, Grattan Street, Parkville VIC 3050, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Christiane Hampe
Received: 10 November 2016 / Revised: 28 February 2017 / Accepted: 6 March 2017 / Published: 5 April 2017
(This article belongs to the Special Issue Auto-Antibody and Autoimmune Disease)
View Full-Text   |   Download PDF [1046 KB, uploaded 5 April 2017]   |  

Abstract

Serum autoantibodies to cyclic citrullinated peptides (anti-CCP) and rheumatoid factor (RF) are important markers for diagnosis and prognosis of rheumatoid arthritis (RA), but their autoantigens are not cartilage-specific. Autoantibodies to joint-specific type II collagen (CII) also occur in RA, and monoclonal antibodies of similar specificity induce collagen antibody-induced arthritis in animals, but their role in RA is uncertain. We utilized an enzyme-linked immunosorbent assay (ELISA) with the CB10 peptide of CII to compare the frequency of autoantibodies with those of anti-CCP and RF in stored sera from a prospective study of 82 patients with early RA to examine the outcome, defined as remission (n = 23), persisting non-erosive arthritis (n = 27), or erosions (n = 32). Initial frequencies of anti-CB10, anti-CCP and RF were 76%, 54%, and 57% in RA, and 4%, 0%, and 9% in 136 controls. The frequency of anti-CB10 was unrelated to outcome, but anti-CCP and RF increased with increasing severity, and the number of autoantibodies mirrored the severity. We suggest RA is an immune complex-mediated arthritis in which the three antibodies interact, with anti-CII inducing localized cartilage damage and inflammation resulting in citrullination of joint proteins, neoepitope formation, and a strong anti-CCP response in genetically-susceptible subjects, all amplified and modified by RF. View Full-Text
Keywords: rheumatoid arthritis; collagen antibodies; anti-citrullinated protein antibodies; rheumatoid factor; immune complexes rheumatoid arthritis; collagen antibodies; anti-citrullinated protein antibodies; rheumatoid factor; immune complexes
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Whittingham, S.F.; Stockman, A.; Rowley, M.J. Collagen Autoantibodies and Their Relationship to CCP Antibodies and Rheumatoid Factor in the Progression of Early Rheumatoid Arthritis. Antibodies 2017, 6, 6.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibodies EISSN 2073-4468 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top