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Antibodies 2016, 5(2), 16; doi:10.3390/antib5020016

The Significance of Anti-Beta-2-Glycoprotein I Antibodies in Antiphospholipid Syndrome

Department of Clinical Immunology, PathWest, Sir Charles Gairdner Hospital, Perth WA 6009, Australia
Academic Editor: Ricard Cervera
Received: 26 April 2016 / Revised: 24 May 2016 / Accepted: 3 June 2016 / Published: 8 June 2016
(This article belongs to the Special Issue Antiphospholipid Antibodies and Syndrome)
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Abstract

Antiphospholipid syndrome (APS) is a thrombophilic disorder that classically presents with vascular thrombosis and/or obstetric complications. APS is associated with antiphospholipid antibodies: a heterogeneous group of autoantibodies that are directed against membrane phospholipids in complex with phospholipid-binding proteins. Beta-2-glycoprotein I (B2GPI) binds anionic phospholipids and is considered to be the predominant antigen in APS and antibodies against B2GPI (anti-B2GPI) are recognised in the laboratory criteria for APS diagnosis. This review focuses on the part played by anti-B2GPI in the pathogenesis of APS, their associations with different clinical phenotypes of the disorder and new avenues for refining the diagnostic potential of anti-B2GPI testing. View Full-Text
Keywords: antiphospholipid syndrome; antiphospholipid antibody; beta-2 glycoprotein I; isotypes; domain specific antibodies antiphospholipid syndrome; antiphospholipid antibody; beta-2 glycoprotein I; isotypes; domain specific antibodies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Brusch, A. The Significance of Anti-Beta-2-Glycoprotein I Antibodies in Antiphospholipid Syndrome. Antibodies 2016, 5, 16.

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