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Antibodies 2016, 5(3), 17; doi:10.3390/antib5030017

Antiphospholipid Syndrome and Kidney Involvement: New Insights

1
Department of Immunology, Instituto de Investigación Hospital Universitario 12 de Octubre, 28041 Madrid, Spain
2
Immunology Section, Universidad San Pablo-CEU, 28660 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Ricard Cervera
Received: 18 May 2016 / Revised: 1 July 2016 / Accepted: 1 July 2016 / Published: 11 July 2016
(This article belongs to the Special Issue Antiphospholipid Antibodies and Syndrome)
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Abstract

Antiphospholipid syndrome is an autoimmune disorder characterized by vascular thromboses and pregnancy morbidity associated with antiphospholipid antibodies: lupus anticoagulant, IgG or IgM anticardiolipin or anti-beta 2-glycoprotein I. The kidney is one of the major target organs in antiphospholipid syndrome (APS). However, beyond the known involvement of the kidney in primary and associated APS, we may be observing a new form of APS within the context of renal failure. This review describes the classical kidney manifestations of APS and provides new considerations to be taken into account. View Full-Text
Keywords: autoimmunity; antiphospholipid antibodies; end stage kidney disease; early graft loss; thrombosis antiphospholipid syndrome; aPL; B2GPI; IgA autoimmunity; antiphospholipid antibodies; end stage kidney disease; early graft loss; thrombosis antiphospholipid syndrome; aPL; B2GPI; IgA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Martínez-Flores, J.A.; Serrano, M.; Morales, J.M.; Serrano, A. Antiphospholipid Syndrome and Kidney Involvement: New Insights. Antibodies 2016, 5, 17.

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