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Welcome to Antibodies: A New Open Access, Multidisciplinary Journal
Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan
Laboratory for Lymphocyte Differentiation, RIKEN RCAI, Yokohama 230-0045, Japan
Received: 15 December 2011; Accepted: 23 December 2011 / Published: 30 December 2011
Abstract: Secreted antibodies are a key player for exerting appropriate humoral immunity. For instance, in infectious diseases, poly-specific “natural” antibodies provide early protection, independent of T cell help. If this line of defense is crossed, T cell-dependent immune responses then generate a humoral memory provided by long-lived plasma cells secreting specific antibodies of adapted avidity and isotype. Secreted antibodies provide an efficient line of defense against re-infection and are backed up by specific memory B and T cells. In the field of humoral immunity, great discoveries including identification of a special T cell subset helping B cell activation (TFH), have been made in a last couple of years; however, important questions (such as mechanisms for affinity maturation of antibodies) still remain. [...]
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Kurosaki, T. Welcome to Antibodies: A New Open Access, Multidisciplinary Journal. Antibodies 2012, 1, 1.
Kurosaki T. Welcome to Antibodies: A New Open Access, Multidisciplinary Journal. Antibodies. 2012; 1(1):1.
Kurosaki, Tomohiro. 2012. "Welcome to Antibodies: A New Open Access, Multidisciplinary Journal." Antibodies 1, no. 1: 1.