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Antibodies 2012, 1(1), 1; doi:10.3390/antib1010001

Welcome to Antibodies: A New Open Access, Multidisciplinary Journal

Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan
Laboratory for Lymphocyte Differentiation, RIKEN RCAI, Yokohama 230-0045, Japan
Received: 15 December 2011 / Accepted: 23 December 2011 / Published: 30 December 2011
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Note: In lieu of an abstract, this is an excerpt from the first page.


Secreted antibodies are a key player for exerting appropriate humoral immunity. For instance, in infectious diseases, poly-specific “natural” antibodies provide early protection, independent of T cell help. If this line of defense is crossed, T cell-dependent immune responses then generate a humoral memory provided by long-lived plasma cells secreting specific antibodies of adapted avidity and isotype. Secreted antibodies provide an efficient line of defense against re-infection and are backed up by specific memory B and T cells. In the field of humoral immunity, great discoveries including identification of a special T cell subset helping B cell activation (TFH), have been made in a last couple of years; however, important questions (such as mechanisms for affinity maturation of antibodies) still remain. [...]
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kurosaki, T. Welcome to Antibodies: A New Open Access, Multidisciplinary Journal. Antibodies 2012, 1, 1.

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