• Submit to Antibodies Login Register
• MDPI
• Journals A-Z
• For Authors
• For Editors
• About
• Open Access Policy

• Abstract
• Full-Text PDF [135 KB]
• Full-Text XML
• Article Versions Notes

• Article Statistics
• Google Scholar
• Order Reprints

• Cite this article
• Export to BibTeX
• Export to EndNote

• [+] on DOAJ
• Kurosaki, T
• [+] on Google Scholar
• Kurosaki, T
• [+] on PubMed
• Kurosaki, T

•  CiteULike
•  Facebook
•  Mendeley
•  Twitter

This article is

• freely available
• re-usable

Antibodies 2012, 1(1), 1; doi:10.3390/antib1010001

Editorial

Welcome to Antibodies: A New Open Access, Multidisciplinary Journal

Tomohiro Kurosaki ^1,2

¹ Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan ² Laboratory for Lymphocyte Differentiation, RIKEN RCAI, Yokohama 230-0045, Japan

Received: 15 December 2011 / Accepted: 23 December 2011 / Published: 30 December 2011

Download PDF Full-Text [135 KB, uploaded 30 December 2011 16:08 CET]

Abstract: Secreted antibodies are a key player for exerting appropriate humoral immunity. For instance, in infectious diseases, poly-specific “natural” antibodies provide early protection, independent of T cell help. If this line of defense is crossed, T cell-dependent immune responses then generate a humoral memory provided by long-lived plasma cells secreting specific antibodies of adapted avidity and isotype. Secreted antibodies provide an efficient line of defense against re-infection and are backed up by specific memory B and T cells. In the field of humoral immunity, great discoveries including identification of a special T cell subset helping B cell activation (TFH), have been made in a last couple of years; however, important questions (such as mechanisms for affinity maturation of antibodies) still remain. [...]

Article Statistics

Cite This Article