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Cells 2017, 6(4), 33; doi:10.3390/cells6040033

A Perspective on the Experimental Techniques for Studying Lamins

Department of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy
The two authors share co-authorship.
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Received: 11 August 2017 / Revised: 1 October 2017 / Accepted: 5 October 2017 / Published: 10 October 2017
(This article belongs to the Collection Lamins and Laminopathies)
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Abstract

Lamins are type V intermediate filaments that collectively form a meshwork underneath the inner nuclear membrane, called nuclear lamina. Furthermore, they are also present in the nucleoplasm. Lamins are experiencing a growing interest, since a wide range of diseases are induced by mutations in the gene coding for A-type lamins, globally known as laminopathies. Moreover, it has been demonstrated that lamins are involved in other pathological conditions, like cancer. The role of lamins has been studied from several perspectives, exploiting different techniques and procedures. This multidisciplinary approach has contributed to resolving the unique features of lamins and has provided a thorough insight in their role in living organisms. Yet, there are still many unanswered questions, which constantly generate research in the field. The present work is aimed to review some interesting experimental techniques performed so far to study lamins. Scientists can take advantage of this collection for their novel investigations, being aware of the already pursued and consolidated methodologies. Hopefully, advances in these research directions will provide insights to achieve better diagnostic procedures and effective therapeutic options. View Full-Text
Keywords: lamins; experimental techniques; microscopy; spectroscopy; mechanics lamins; experimental techniques; microscopy; spectroscopy; mechanics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pecorari, I.; Borin, D.; Sbaizero, O. A Perspective on the Experimental Techniques for Studying Lamins. Cells 2017, 6, 33.

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