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Cells 2016, 5(2), 27; doi:10.3390/cells5020027

Under Pressure: Mechanical Stress Management in the Nucleus

1
Institut National de la Santé et de la Recherche Médicale, UMR 1087, l’institut du thorax, CNRS, UMR 6291, Université de Nantes, 44000 Nantes, France
2
Institut National de la Santé et de la Recherche Médicale, UMR 1209, Institute for Advanced Biosciences, CNRS UMR 5309, Université Grenoble Alpes, 38041 Grenoble, France
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Dechat
Received: 28 April 2016 / Revised: 3 June 2016 / Accepted: 6 June 2016 / Published: 14 June 2016
(This article belongs to the Collection Lamins and Laminopathies)
View Full-Text   |   Download PDF [1107 KB, uploaded 14 June 2016]   |  

Abstract

Cells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback, which hinges on mechanotransduction mechanisms. Whereas adhesion structures have been shown to play a central role in mechanotransduction, it now emerges that the nucleus may act as a mechanosensitive structure. Here, we review recent advances demonstrating that mechanical stress emanating from the cytoskeleton can activate pathways in the nucleus which eventually impact both its structure and the transcriptional machinery. View Full-Text
Keywords: mechanotransduction; nucleoskeleton; lamina; lamin; LINC; nucleus; mechanical stress mechanotransduction; nucleoskeleton; lamina; lamin; LINC; nucleus; mechanical stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Belaadi, N.; Aureille, J.; Guilluy, C. Under Pressure: Mechanical Stress Management in the Nucleus. Cells 2016, 5, 27.

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