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Cells 2016, 5(1), 7; doi:10.3390/cells5010007

Functions of Rab Proteins at Presynaptic Sites

1
Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen 37077, Germany
2
Interactomics and Intracellular Trafficking laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore
3
Neurobiology/Ageing Programme, National University of Singapore, Singapore 117456, Singapore
4
Research Group Protein trafficking in synaptic development and function, Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen 37077, Germany
*
Author to whom correspondence should be addressed.
Received: 12 January 2016 / Accepted: 3 February 2016 / Published: 6 February 2016
(This article belongs to the Special Issue Regulation and Function of Small GTPases)
View Full-Text   |   Download PDF [641 KB, uploaded 19 February 2016]   |  

Abstract

Presynaptic neurotransmitter release is dominated by the synaptic vesicle (SV) cycle and entails the biogenesis, fusion, recycling, reformation or turnover of synaptic vesicles—a process involving bulk movement of membrane and proteins. As key mediators of membrane trafficking, small GTPases from the Rab family of proteins play critical roles in this process by acting as molecular switches that dynamically interact with and regulate the functions of different sets of macromolecular complexes involved in each stage of the cycle. Importantly, mutations affecting Rabs, and their regulators or effectors have now been identified that are implicated in severe neurological and neurodevelopmental disorders. Here, we summarize the roles and functions of presynaptic Rabs and discuss their involvement in the regulation of presynaptic function. View Full-Text
Keywords: Presynapse; synaptic transmission; small GTPases; Rabs; intracellular membrane trafficking; synaptic vesicle cycle; autophagy Presynapse; synaptic transmission; small GTPases; Rabs; intracellular membrane trafficking; synaptic vesicle cycle; autophagy
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Binotti, B.; Jahn, R.; Chua, J.J.E. Functions of Rab Proteins at Presynaptic Sites. Cells 2016, 5, 7.

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