Cells 2013, 2(2), 432-459; doi:10.3390/cells2020432
Review

Apoptotic Cell Death in Neuroblastoma

 and *
Received: 10 May 2013; in revised form: 30 May 2013 / Accepted: 8 June 2013 / Published: 20 June 2013
(This article belongs to the Special Issue Apoptosis)
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Abstract: Neuroblastoma (NB) is one of the most common malignant solid tumors in childhood, which derives from the sympathoadrenal lineage of the neural crest and exhibits extremely heterogeneous biological and clinical behaviors. The infant patients frequently undergo spontaneous regression even with metastatic disease, whereas the patients of more than one year of age who suffer from disseminated disease have a poor outcome despite intensive multimodal treatment. Spontaneous regression in favorable NBs has been proposed to be triggered by nerve growth factor (NGF) deficiency in the tumor with NGF dependency for survival, while aggressive NBs have defective apoptotic machinery which enables the tumor cells to evade apoptosis and confers the resistance to treatment. This paper reviews the molecules and pathways that have been recently identified to be involved in apoptotic cell death in NB and discusses their potential prospects for developing more effective therapeutic strategies against aggressive NB.
Keywords: neuroblastoma; spontaneous regression; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, Y.; Nakagawara, A. Apoptotic Cell Death in Neuroblastoma. Cells 2013, 2, 432-459.

AMA Style

Li Y, Nakagawara A. Apoptotic Cell Death in Neuroblastoma. Cells. 2013; 2(2):432-459.

Chicago/Turabian Style

Li, Yuanyuan; Nakagawara, Akira. 2013. "Apoptotic Cell Death in Neuroblastoma." Cells 2, no. 2: 432-459.


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