Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Methods
2.2.1. Synthesis of Bis(thiobenzoyl) Disulfide, (2-Cyanoprop-2-yl Dithiobenzoate), and Disulfide Diacrylate (DSDA)
2.2.2. Preparation of PEGMEMA–PPGMA–DSDA Copolymers via One-Pot RAFT Polymerisation
2.2.3. Characterisation of PEGMEMA–PPGMA–DSDA Copolymers
2.2.4. Fabrication of Hydrogels by Thermal Gelation
2.2.5. Fabrication of Hydrogels by Michael Addition Reaction
2.2.6. Swelling Studies
2.2.7. Reducibility Studies
3. Results and Discussion
3.1. Synthesis and Characterisation of Reducible and Thermoresponsive Hyperbranched Polymers via One-Pot RAFT Polymerisation
3.2. Determination of Lower Critical Solution Temperatures (LCST) and the Formation of Physical Gels
3.3. Fabrication of Chemical Cross-Linked Hydrogels from Thiol-Ene Michael Addition Reaction Using PEGMEMA–PPGMA–DSDA Copolymers
3.4. Swelling
3.5. Reducibility
4. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Entry | Polymer samples obtained | f a | RT b (h) | Cov c % | GPC RI | LCST °C | |||
---|---|---|---|---|---|---|---|---|---|
Mw d | Mn e | PDI f | LCST g | LCST h | |||||
kg/mol | kg/mol | ||||||||
1 | R1 | 70:20:10:5:1 | 48 | 95 | 12.7 | 9.0 | 1.40 | - | - |
2 | R2 | 50:40:10:2:0.4 | 24 | 80 | 7.3 | 6.6 | 1.12 | 55 | 56 |
3 | R3 | 50:40:10:1:0.2 | 24 | 64 | 11.3 | 9.8 | 1.15 | 57 | 57 |
4 | R4 | 20:70:10:1:0.2 | 29 | 54 | 12.4 | 10.1 | 1.22 | 28 | 28 |
5 | R5 | 15:65:20:1:0.2 | 25 | 58 | 11.2 | 8.9 | 1.26 | 22 | 23 |
6 | R6 | 20:70:10:1:0.2 | 17 | 65 | 13.4 | 11.4 | 1.17 | 28 | 30 |
7 | R7 | 20:70:10:0.5:0.1 | 11 | 46 | 10.2 | 8.7 | 1.16 | 18 | 17 |
Polymer samples | f a PEGMEMA:PPGMA:DSDA | f b PEGMEMA:PPGMA:DSDA | Double bond (mol %) | Branching degree (mol %) |
---|---|---|---|---|
R4 | 20:70:10 | 24:49:27 | 0.5 | 45.9 |
R7 | 20:70:10 | 22:45:33 | 1 | 61.7 |
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Tochwin, A.; El-Betany, A.; Tai, H.; Chan, K.Y.; Blackburn, C.; Wang, W. Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation. Polymers 2017, 9, 443. https://doi.org/10.3390/polym9090443
Tochwin A, El-Betany A, Tai H, Chan KY, Blackburn C, Wang W. Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation. Polymers. 2017; 9(9):443. https://doi.org/10.3390/polym9090443
Chicago/Turabian StyleTochwin, Anna, Alaa El-Betany, Hongyun Tai, Kai Yu Chan, Chester Blackburn, and Wenxin Wang. 2017. "Thermoresponsive and Reducible Hyperbranched Polymers Synthesized by RAFT Polymerisation" Polymers 9, no. 9: 443. https://doi.org/10.3390/polym9090443