Next Article in Journal
Enhanced Stimuli-Responsive Electrorheological Property of Poly(ionic liquid)s-Capsulated Polyaniline Particles
Previous Article in Journal
Use of Bacterial Cellulose and Crosslinked Cellulose Nanofibers Membranes for Removal of Oil from Oil-in-Water Emulsions
Previous Article in Special Issue
pH Dependence of Chitosan Enzymolysis
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Polymers 2017, 9(9), 389; https://doi.org/10.3390/polym9090389

Synthesis and Nanoprecipitation of HEMA-CLn Based Polymers for the Production of Biodegradable Nanoparticles

1
Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, via Mancinelli 7, 20131 Milan, Italy
2
Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland
*
Author to whom correspondence should be addressed.
Received: 10 July 2017 / Revised: 10 August 2017 / Accepted: 21 August 2017 / Published: 23 August 2017
(This article belongs to the Special Issue Biodegradable Polymers)
Full-Text   |   PDF [1718 KB, uploaded 24 August 2017]   |  

Abstract

The control over the size distribution and stability of polymeric nanoparticles (NPs) is crucial in many of their applications, especially in the biomedical field. These characteristics are typically influenced by the production method and the nature of the starting material. To investigate these aspects, the controlled radical polymerization of functionalized methacrylates constituted by 2-hydroxyethyl methacrylate (HEMA) functionalized with a controlled number of ε-caprolactone (CL) units (HEMA-CLn), was carried out via reversible addition–fragmentation chain transfer polymerization (RAFT) in solution. The living reaction allows for good control over the molar mass of the final polymer with a low molar mass dispersity. The obtained polymer solutions were nanoprecipitated in order to produce NPs suitable for drug delivery applications with narrow particle size distribution and a wide size range (from 60 to 250 nm). The NP synthesis has been performed using a mixing device, in order to control the parameters involved in the nanoprecipitation process. As already seen for similar systems, the size of the produced NPs is a function of the polymer concentration during the nanoprecipitation process. Nevertheless, when the polymer concentration is kept constant, the NP size is influenced by the chemical structure of the polymer used, in terms of the presence of PEG (poly(ethylene glycol)), the degree of RAFT polymerization, and the length of the caprolactone side chain. These characteristics were also found to influence the stability and degradation properties of the produced NPs. View Full-Text
Keywords: RAFT polymerization; nanoparticles; poly(ε-caprolactone); nanoprecipitation; degradation RAFT polymerization; nanoparticles; poly(ε-caprolactone); nanoprecipitation; degradation
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Gatti, S.; Agostini, A.; Ferrari, R.; Moscatelli, D. Synthesis and Nanoprecipitation of HEMA-CLn Based Polymers for the Production of Biodegradable Nanoparticles. Polymers 2017, 9, 389.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top