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Polymers 2017, 9(2), 40; doi:10.3390/polym9020040

Engineering Cell Surfaces with Polyelectrolyte Materials for Translational Applications

1
Fischell Department of Bioengineering, University of Maryland, College Park, MA 20742, USA
2
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MA 21201, USA
3
Marlene and Stewart Greenebaum Cancer Center, Baltimore, MA 21201, USA
4
United States Department of Veterans Affairs, Baltimore, MA 21201, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Roland G. Winkler
Received: 11 December 2016 / Revised: 18 January 2017 / Accepted: 19 January 2017 / Published: 28 January 2017
(This article belongs to the Collection Polyelectrolytes)
View Full-Text   |   Download PDF [4330 KB, uploaded 28 January 2017]   |  

Abstract

Engineering cell surfaces with natural or synthetic materials is a unique and powerful strategy for biomedical applications. Cells exhibit more sophisticated migration, control, and functional capabilities compared to nanoparticles, scaffolds, viruses, and other engineered materials or agents commonly used in the biomedical field. Over the past decade, modification of cell surfaces with natural or synthetic materials has been studied to exploit this complexity for both fundamental and translational goals. In this review we present the existing biomedical technologies for engineering cell surfaces with one important class of materials, polyelectrolytes. We begin by introducing the challenges facing the cell surface engineering field. We then discuss the features of polyelectrolytes and how these properties can be harnessed to solve challenges in cell therapy, tissue engineering, cell-based drug delivery, sensing and tracking, and immune modulation. Throughout the review, we highlight opportunities to drive the field forward by bridging new knowledge of polyelectrolytes with existing translational challenges. View Full-Text
Keywords: polyelectrolyte; multilayer; cell modification; sensing and signaling; drug delivery; vaccine and immunotherapy; surface protein; tissue engineering; regenerative medicine polyelectrolyte; multilayer; cell modification; sensing and signaling; drug delivery; vaccine and immunotherapy; surface protein; tissue engineering; regenerative medicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, P.; Bookstaver, M.L.; Jewell, C.M. Engineering Cell Surfaces with Polyelectrolyte Materials for Translational Applications. Polymers 2017, 9, 40.

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