The In Vitro Enzymatic Degradation of Cross-Linked Poly(trimethylene carbonate) Networks
AbstractThe in vitro enzymatic degradation of cross-linked poly(trimethylene carbonate) networks (PTMC-Ns) was performed in lipase solutions at 37 °C, and the effect of the initial molecular weight and cross-linker amount as well as the cross-linker type on the degradation rate of PTMC-Ns was investigated. Due to their denser structure and more hydrophobic surface as well as the higher glass transition temperature, a slower degradation rate was seen for PTMC-Ns with high initial molecular weight at a given cross-linker amount. Similar results could be observed as the cross-linker amount increased, and cross-linker type also influenced the degradation rate of PTMC-Ns. Furthermore, the enzymatic degradation of PTMC-Ns was accelerated by the surfactants role of lipase via surface erosion mechanism, the enzymatic degradation rate was higher than that of hydrolysis case. The results indicated that PTMC-Ns were promising candidates for clinical subcutaneous implants, especially due to their tunable degradation rate and enhanced form-stability as well as no acidic degradation products. View Full-Text
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Hou, Z.; Hu, J.; Li, J.; Zhang, W.; Li, M.; Guo, J.; Yang, L.; Chen, Z. The In Vitro Enzymatic Degradation of Cross-Linked Poly(trimethylene carbonate) Networks. Polymers 2017, 9, 605.
Hou Z, Hu J, Li J, Zhang W, Li M, Guo J, Yang L, Chen Z. The In Vitro Enzymatic Degradation of Cross-Linked Poly(trimethylene carbonate) Networks. Polymers. 2017; 9(11):605.Chicago/Turabian Style
Hou, Zhipeng; Hu, Jianshe; Li, Jianxin; Zhang, Wei; Li, Miao; Guo, Jing; Yang, Liqun; Chen, Zhangpei. 2017. "The In Vitro Enzymatic Degradation of Cross-Linked Poly(trimethylene carbonate) Networks." Polymers 9, no. 11: 605.