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Polymers 2017, 9(11), 605; https://doi.org/10.3390/polym9110605

The In Vitro Enzymatic Degradation of Cross-Linked Poly(trimethylene carbonate) Networks

1
Center for Molecular Science and Engineering, College of Science, Northeastern University, Shenyang 110819, China
2
Key Laboratory of Reproductive Health and Medical Genetics, National Health and Family Planning Commission, Shenyang 110031, China
3
Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, Shenyang 110031, China
*
Authors to whom correspondence should be addressed.
Received: 5 October 2017 / Revised: 27 October 2017 / Accepted: 8 November 2017 / Published: 13 November 2017
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Abstract

The in vitro enzymatic degradation of cross-linked poly(trimethylene carbonate) networks (PTMC-Ns) was performed in lipase solutions at 37 °C, and the effect of the initial molecular weight and cross-linker amount as well as the cross-linker type on the degradation rate of PTMC-Ns was investigated. Due to their denser structure and more hydrophobic surface as well as the higher glass transition temperature, a slower degradation rate was seen for PTMC-Ns with high initial molecular weight at a given cross-linker amount. Similar results could be observed as the cross-linker amount increased, and cross-linker type also influenced the degradation rate of PTMC-Ns. Furthermore, the enzymatic degradation of PTMC-Ns was accelerated by the surfactants role of lipase via surface erosion mechanism, the enzymatic degradation rate was higher than that of hydrolysis case. The results indicated that PTMC-Ns were promising candidates for clinical subcutaneous implants, especially due to their tunable degradation rate and enhanced form-stability as well as no acidic degradation products. View Full-Text
Keywords: cross-linked poly(trimethylene carbonate) networks; enzymatic degradation; initial molecular weight; cross-linker amount; form-stability cross-linked poly(trimethylene carbonate) networks; enzymatic degradation; initial molecular weight; cross-linker amount; form-stability
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Hou, Z.; Hu, J.; Li, J.; Zhang, W.; Li, M.; Guo, J.; Yang, L.; Chen, Z. The In Vitro Enzymatic Degradation of Cross-Linked Poly(trimethylene carbonate) Networks. Polymers 2017, 9, 605.

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