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Polymers 2017, 9(1), 20; doi:10.3390/polym9010020

Multi-Objective Optimizations of Biodegradable Polymer Stent Structure and Stent Microinjection Molding Process

1
School of Mechanical Engineering, Dalian University of Technology, Dalian 116023, China
2
Department of Engineering Mechanics, State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian 116023, China
3
College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
*
Author to whom correspondence should be addressed.
Academic Editor: Xianqiao Wang
Received: 18 October 2016 / Revised: 26 December 2016 / Accepted: 30 December 2016 / Published: 17 January 2017
(This article belongs to the Special Issue Computational Modeling and Simulation in Polymer)
View Full-Text   |   Download PDF [4504 KB, uploaded 17 January 2017]   |  

Abstract

Biodegradable stents made of poly-l-lactic acid (PLLA) have a promising prospect thanks to high biocompatibility and a favorable biodegradation period. However, due to the low stiffness of PLLA, polymeric stents have a lower radial stiffness and larger foreshortening. Furthermore, a stent is a tiny meshed tube, hence, it is difficult to make a polymeric stent. In the present study, a finite element analysis-based optimization method combined with Kriging surrogate modeling is firstly proposed to optimize the stent structure and stent microinjection molding process, so as to improve the stent mechanical properties and microinjection molding quality, respectively. The Kriging surrogate models are constructed to formulate the approximate mathematical relationships between the design variables and design objectives. Expected improvement is employed to balance local and global search to find the global optimal design. As an example, the polymeric ART18Z stent was investigated. The mechanical properties of stent expansion in a stenotic artery and the molding quality were improved after optimization. Numerical results demonstrate the proposed optimization method can be used for the computationally measurable optimality of stent structure design and stent microinjection molding process. View Full-Text
Keywords: biodegradable polymer; stent; expansion performance; injection molding; kriging; multi-objective optimization biodegradable polymer; stent; expansion performance; injection molding; kriging; multi-objective optimization
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Li, H.; Wang, X.; Wei, Y.; Liu, T.; Gu, J.; Li, Z.; Wang, M.; Zhao, D.; Qiao, A.; Liu, Y. Multi-Objective Optimizations of Biodegradable Polymer Stent Structure and Stent Microinjection Molding Process. Polymers 2017, 9, 20.

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