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Polymers 2016, 8(5), 198; doi:10.3390/polym8050198

Supramolecular Nanostructures Based on Cyclodextrin and Poly(ethylene oxide): Syntheses, Structural Characterizations and Applications for Drug Delivery

1
Department of internal medicine, The First Hospital in Qinhuangdao Affiliated to Hebei Medical University, Qinhuangdao 066004, China
2
Department of Chemistry, Queen’s University, Kingston, ON K7L 3N6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Received: 1 March 2016 / Revised: 10 May 2016 / Accepted: 10 May 2016 / Published: 17 May 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
View Full-Text   |   Download PDF [3117 KB, uploaded 17 May 2016]   |  

Abstract

Cyclodextrins (CDs) have been extensively studied as drug delivery carriers through host–guest interactions. CD-based poly(pseudo)rotaxanes, which are composed of one or more CD rings threading on the polymer chain with or without bulky groups (or stoppers), have attracted great interest in the development of supramolecular biomaterials. Poly(ethylene oxide) (PEO) is a water-soluble, biocompatible polymer. Depending on the molecular weight, PEO can be used as a plasticizer or as a toughening agent. Moreover, the hydrogels of PEO are also extensively studied because of their outstanding characteristics in biological drug delivery systems. These biomaterials based on CD and PEO for controlled drug delivery have received increasing attention in recent years. In this review, we summarize the recent progress in supramolecular architectures, focusing on poly(pseudo)rotaxanes, vesicles and supramolecular hydrogels based on CDs and PEO for drug delivery. Particular focus will be devoted to the structures and properties of supramolecular copolymers based on these materials as well as their use for the design and synthesis of supramolecular hydrogels. Moreover, the various applications of drug delivery techniques such as drug absorption, controlled release and drug targeting based CD/PEO supramolecular complexes, are also discussed. View Full-Text
Keywords: supramolecular polymers; cyclodextrins (CDs); poly(ethylene oxide); syntheses; structure; drug delivery supramolecular polymers; cyclodextrins (CDs); poly(ethylene oxide); syntheses; structure; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zheng, Y.; Wyman, I.W. Supramolecular Nanostructures Based on Cyclodextrin and Poly(ethylene oxide): Syntheses, Structural Characterizations and Applications for Drug Delivery. Polymers 2016, 8, 198.

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