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Polymers 2016, 8(5), 182; doi:10.3390/polym8050182

Hydrogel is Superior to Fibrin Gel as Matrix of Stem Cells in Alleviating Antigen-Induced Arthritis

1
Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, China
2
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3
Department of orthopedics, Hallym University, Hallymdaehak-gil 1, Chuncheon 200-702, Korea
4
Academy of Translational Medicine, The First Bethune Hospital of Jilin University, Changchun 130021, China
5
Hand & Foot Surgery and Reparative & Reconstruction Surgery Center, Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, China
*
Author to whom correspondence should be addressed.
Academic Editor: Christine Wandrey
Received: 16 March 2016 / Revised: 31 March 2016 / Accepted: 28 April 2016 / Published: 6 May 2016
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Abstract

Recently, therapy with bone marrow mesenchymal stem cells (BMMSCs) has been attempted to relieve rheumatoid arthritis (RA) and reconstruct cartilage injury. However, treatment has been unsuccessful in complete prevention of persistent cartilage destruction and resulted in inferior outcomes of cartilage regeneration. Scaffolds are an important construct in the field of cartilage tissue engineering, but their role in arthritis treatment has not yet been fully examined. Here, we transplanted two types of scaffold-assisted BMMSCs: fibrin gel- and poly(l-lactide-co-glycolide)−poly(ethylene glycol)−poly(l-lactide-co-glycolide) (PLGA−PEG−PLGA) hydrogel-assisted BMMSCs referred as FGB and HGB groups, respectively, into subchondral defects for the treatment of antigen-induced arthritis. The administration of exogenous BMMSCs ameliorated joint swelling and decreased both joint surface temperature and inflammatory cytokine levels in both groups. Immune cell composition of the inflammation of surrounding synovium, protection of adjacent cartilage, and improved cartilage repair were also observed. Overall, the HGB group had a better therapeutic efficacy than the FGB group. In conclusion, local transplantation of BMMSCs in subchondral defects presents a novel approach in inducing RA remission and recovery of RA-induced cartilage injury. To induce these changes, the selection of scaffold for cell support is exceedingly important. Further studies are needed regarding the treatment options of subchondral defects in arthritis based on modified scaffold development, application of defined MSCs sources, combination of pharmacotherapeutics, and the addition of factors that inhibit the processes of RA remission, promote the recovery of RA-induced cartilage injury and the relationship between these factors. View Full-Text
Keywords: bone marrow mesenchymal stem cells; cartilage repair; fibrin gel; hydrogel; ovalbumin-induced arthritis; rheumatoid arthritis bone marrow mesenchymal stem cells; cartilage repair; fibrin gel; hydrogel; ovalbumin-induced arthritis; rheumatoid arthritis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liu, H.; Ding, J.; Li, C.; Wang, C.; Wang, Y.; Wang, J.; Chang, F. Hydrogel is Superior to Fibrin Gel as Matrix of Stem Cells in Alleviating Antigen-Induced Arthritis. Polymers 2016, 8, 182.

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