Next Article in Journal
Rheological and Mechanical Behavior of Silk Fibroin Reinforced Waterborne Polyurethane
Previous Article in Journal
Preparation of Uniform-Sized and Dual Stimuli-Responsive Microspheres of Poly(N-Isopropylacrylamide)/Poly(Acrylic acid) with Semi-IPN Structure by One-Step Method
Article Menu

Export Article

Open AccessArticle
Polymers 2016, 8(3), 92; doi:10.3390/polym8030092

Studies on Preparation of Poly(3,4-Dihydroxyphenylalanine)-Polylactide Copolymers and the Effect of the Structure of the Copolymers on Their Properties

The Key Laboratory of Food Colloids and Biotechnology Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Ji Ho Youk
Received: 4 February 2016 / Revised: 9 March 2016 / Accepted: 10 March 2016 / Published: 18 March 2016
View Full-Text   |   Download PDF [2805 KB, uploaded 18 March 2016]   |  

Abstract

Properties of copolymers are generally influenced by the structure of the monomers and polymers. For the purpose of understanding the effect of polymer structure on the properties, two kinds of copolymers, poly(3,4-dihydroxyphenylalanine)-g-polylactide and poly(3,4-dihydroxyphenylalanine)-b-polylactide (PDOPA-g-PLA and PDOPA-b-PLA) were designed and prepared by ring-opening polymerization of lactide with pre-prepared PDOPA as the initiator and the amidation of the functional PLA and PDOPA oligomer, respectively. The molecular weight and composition of the copolymers could be adjusted by changing the molar ratio of LA and DOPA and were confirmed by gel permeation chromatography (GPC) and proton nuclear magnetic resonance (1H NMR) spectra. The obtained copolymers with graft and block structures showed high solubility even in common organic solvents. The effects of the graft and block structures on the thermal and degradation properties were also detected. The PDOPA-g-PLA copolymers showed higher thermal stability than the PDOPA-b-PLA copolymers, due to the PDOPA-g-PLA copolymers with regular structure and strong π-π stacking interactions among the intermolecular and intramolecular chains. In addition, the degradation results showed that the PDOPA-g-PLA copolymers and the copolymers with higher DOPA composition had quicker degradation speeds. Interestingly, both two kinds of copolymers, after degradation, became undissolved in the organic solvents because of the oxidation and crosslinking formation of the catechol groups in the DOPA units during degradation in alkaline solution. Moreover, fluorescent microscopy results showed good biocompatibility of the PDOPA-g-PLA and PDOPA-b-PLA copolymers. The PDOPA and PLA copolymers have the potential applications to the biomedical and industrial fields. View Full-Text
Keywords: bio-based copolymer; polylactide; 3,4-dihydroxyphenylalanine; degradability; biocompatibility bio-based copolymer; polylactide; 3,4-dihydroxyphenylalanine; degradability; biocompatibility
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shi, D.; Shen, J.; Zhao, Z.; Shi, C.; Chen, M. Studies on Preparation of Poly(3,4-Dihydroxyphenylalanine)-Polylactide Copolymers and the Effect of the Structure of the Copolymers on Their Properties. Polymers 2016, 8, 92.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top