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Polymers 2016, 8(12), 418; doi:10.3390/polym8120418

Hydrogel Layers on the Surface of Polyester-Based Materials for Improvement of Their Biointeractions and Controlled Release of Proteins

1
Institute of Chemistry, St. Petersburg State University, Universitetskii Pr. 26, Peterhoff, 198504 St. Petersburg, Russia
2
Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoy Pr. 31, 199004 St. Petersburg, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick van Rijn
Received: 11 November 2016 / Revised: 24 November 2016 / Accepted: 28 November 2016 / Published: 2 December 2016
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Abstract

The modification of bioresorbable polyester surfaces in order to alter their biointeractions presents an important problem in biomedical polymer science. In this study, the covalent modification of the surface of poly(lactic acid)-based (PLA-based) films with poly(acryl amide) and sodium alginate hydrogels was performed to change the non-specific polyester interaction with proteins and cells, as well as to make possible the covalent attachment of low-molecular weight ligands and to control protein release. The effect of such modification on the film surface properties was studied. Parameters such as swelling, water contact angle, surface area, and binding capacity of low-molecular weight substances were evaluated and compared. The comparative study of adsorption of model protein (BSA) on the surface of non-modified and modified films was investigated and the protein release was evaluated. Cell viability on the surface of hydrogel-coated films was also tested. The developed approach could be applied for the modification of PLA-based scaffolds for tissue engineering and will be further studied for molecular-imprinting of biomolecules on the surface of polyester-based materials for control of biointeractions. View Full-Text
Keywords: poly(lactic acid); surface modification; hydrogel; protein adsorption; protein release; cell-material interactions poly(lactic acid); surface modification; hydrogel; protein adsorption; protein release; cell-material interactions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Korzhikov-Vlakh, V.; Krylova, M.; Sinitsyna, E.; Ivankova, E.; Averianov, I.; Tennikova, T.B. Hydrogel Layers on the Surface of Polyester-Based Materials for Improvement of Their Biointeractions and Controlled Release of Proteins. Polymers 2016, 8, 418.

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