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Polymers 2016, 8(1), 15; doi:10.3390/polym8010015

Cationic Nanocylinders Promote Angiogenic Activities of Endothelial Cells

1
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA
2
Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37235, USA
3
Department of Internal Medicine, Yonsei University of Wonju College of Medicine, Wonju, Gangwon 220-701, Korea
4
Department of Medical Engineering, College of Medicine, Kyung Hee University, Seoul 130-701, Korea
5
Department of Biomedical Engineering, Inje University, Gimhae 621-749, Korea
6
Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea
7
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37235, USA
8
Severance Biomedical Science Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Esmaiel Jabbari
Received: 30 November 2015 / Revised: 7 January 2016 / Accepted: 11 January 2016 / Published: 14 January 2016
(This article belongs to the Special Issue Polymers Applied in Tissue Engineering)
View Full-Text   |   Download PDF [3915 KB, uploaded 14 January 2016]   |  

Abstract

Polymers have been used extensively taking forms as scaffolds, patterned surface and nanoparticle for regenerative medicine applications. Angiogenesis is an essential process for successful tissue regeneration, and endothelial cell–cell interaction plays a pivotal role in regulating their tight junction formation, a hallmark of angiogenesis. Though continuous progress has been made, strategies to promote angiogenesis still rely on small molecule delivery or nuanced scaffold fabrication. As such, the recent paradigm shift from top-down to bottom-up approaches in tissue engineering necessitates development of polymer-based modular engineering tools to control angiogenesis. Here, we developed cationic nanocylinders (NCs) as inducers of cell–cell interaction and investigated their effect on angiogenic activities of human umbilical vein endothelial cells (HUVECs) in vitro. Electrospun poly (l-lactic acid) (PLLA) fibers were aminolyzed to generate positively charged NCs. The aninolyzation time was changed to produce two different aspect ratios of NCs. When HUVECs were treated with NCs, the electrostatic interaction of cationic NCs with negatively charged plasma membranes promoted migration, permeability and tubulogenesis of HUVECs compared to no treatment. This effect was more profound when the higher aspect ratio NC was used. The results indicate these NCs can be used as a new tool for the bottom-up approach to promote angiogenesis. View Full-Text
Keywords: cationic nanocylinder; cell–cell interaction; endothelial cells; migration; tubulogenesis cationic nanocylinder; cell–cell interaction; endothelial cells; migration; tubulogenesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, J.B.; Balikov, D.A.; Yang, J.W.; Kim, K.S.; Park, H.K.; Kim, J.K.; Kwon, I.K.; Bellan, L.M.; Sung, H.-J. Cationic Nanocylinders Promote Angiogenic Activities of Endothelial Cells. Polymers 2016, 8, 15.

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