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Polymers 2015, 7(9), 1820-1836; doi:10.3390/polym7091484

Conjugation of ß-Adrenergic Antagonist Alprenolol to Implantable Polymer-Aescin Matrices for Local Delivery

1
Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland
2
Department of Environmental Health Science, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Received: 24 July 2015 / Revised: 8 September 2015 / Accepted: 10 September 2015 / Published: 18 September 2015
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
View Full-Text   |   Download PDF [1240 KB, uploaded 18 September 2015]   |  

Abstract

The sustained release of alprenolol, a ß-adrenergic antagonist, could be beneficial for the treatment of various heart diseases while reducing the side effects resulting from its continuous use. The novel and branched copolymers uniquely composed of biodegradable components (lactide and glycolide) have been synthesized using natural and therapeutically-efficient ß-aescin-initiator, and consequently characterized to determine their structures and physicochemical properties. The obtained matrices were not cyto- and genotoxic towards bacterial luminescence, protozoan, and Salmonella typhimurium TA1535. The copolymers release the drug in vitro in a sustained manner and without burst release. The value of the drug released was strongly dependent on the copolymer composition and highly correlated with the hydrolytic matrices’ degradation results. View Full-Text
Keywords: biodegradable polymers; sustained release/delivery; macromolecular drug delivery systems; aescin; alprenolol; conjugation biodegradable polymers; sustained release/delivery; macromolecular drug delivery systems; aescin; alprenolol; conjugation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Oledzka, E.; Pachowska, D.; Sobczak, M.; Lis-Cieplak, A.; Nalecz-Jawecki, G.; Zgadzaj, A.; Kolodziejski, W. Conjugation of ß-Adrenergic Antagonist Alprenolol to Implantable Polymer-Aescin Matrices for Local Delivery. Polymers 2015, 7, 1820-1836.

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