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Polymers 2015, 7(8), 1510-1521; doi:10.3390/polym7081467

Effect of Molar Mass and Water Solubility of Incorporated Molecules on the Degradation Profile of the Triblock Copolymer Delivery System

1
Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo 58105, ND, USA
2
Sterile Product Development, Teva Pharmaceuticals, Pomona 10970, CA, USA
3
Technical & Scientific Affairs, Teva Pharmaceuticals, Salt Lake City 84116, UT, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Sebastien Lecommandoux and Cyrille Boyer
Received: 12 May 2015 / Revised: 25 June 2015 / Accepted: 7 August 2015 / Published: 14 August 2015
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Abstract

The purpose of this study was to investigate the effects of size and type of incorporated model molecules on the polymer degradation and release profile from thermosensitive triblock copolymer based controlled delivery systems. In vitro release of the incorporated molecules demonstrated slow release for risperidone (molecular weight (Mw) = 410.48 Da; partition coefficient (Ko/w) = 3.49), while bovine serum albumin (BSA) (Mw = ~66,400 Da; Ko/w = 0.007) and insulin (Mw = 5808 Da; Ko/w = 0.02) showed initial burst release followed by controlled release. The proton NMR, Gel Permeation Chromatography, and Cryo-SEM studies suggest that the size and partition coefficient of incorporated molecules influence the pore size, polymer degradation, and their release. In spite of using a similar polymer delivery system the polymer degradation rate and drug release notably differ for these model molecules. Therefore, size and oil-water partition coefficient are important factors for designing the controlled release formulation of therapeutics from triblock copolymer based delivery systems. View Full-Text
Keywords: size; oil-water partition coefficient; triblock copolymers; polymer degradation; macromolecules; in vitro release size; oil-water partition coefficient; triblock copolymers; polymer degradation; macromolecules; in vitro release
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Oak, M.; Mandke, R.; Lakkadwala, S.; Lipp, L.; Singh, J. Effect of Molar Mass and Water Solubility of Incorporated Molecules on the Degradation Profile of the Triblock Copolymer Delivery System. Polymers 2015, 7, 1510-1521.

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