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Polymers 2015, 7(10), 2119-2130; doi:10.3390/polym7101504

PEGylated Fluorescent Nanoparticles from One-Pot Atom Transfer Radical Polymerization and “Click Chemistry”

1
Institute for Clean Energy & Advanced Materials, Faculty of Materials & Energy, Southwest University, Chongqing 400715, China
2
Department of Chemical & Biomolecular Engineering, National University of Singapore, Kent Ridge 117576, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Nicolay Tsarevsky
Received: 17 September 2015 / Revised: 2 October 2015 / Accepted: 15 October 2015 / Published: 23 October 2015
(This article belongs to the Special Issue Controlled/Living Radical Polymerization)
View Full-Text   |   Download PDF [4446 KB, uploaded 23 October 2015]   |  

Abstract

The preparation of PEGylated fluorescent nanoparticles (NPs) based on atom transfer radical polymerization (ATRP) and “click chemistry” in one-pot synthesis is presented. First, poly(p-chloromethyl styrene-alt-N-propargylmaleimide) (P(CMS-alt-NPM)) copolymer was prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization. Subsequently, the azido-containing fluorene-based polymer, poly[(9,9-dihexylfluorene)-alt-(9,9-bis-(6-azidohexyl)fluorene)] (PFC6N3), was synthesized via Suzuki coupling polymerization, followed by azidation. Finally, the PEGylated fluorescent NPs were prepared via simultaneous intermolecular “click” cross-linking between P(CMS-alt-NPM) and PFC6N3 and the ATRP of poly(ethylene glycol) methyl ether methacrylate (PEGMMA) using P(CMS-alt-NPM) as the macroinitiator. The low cytotoxicity of the PEGylated fluorescent NPs was revealed by incubation with KB cells, a cell line derived from carcinoma of the nasopharynx, in an in vitro experiment. The biocompatible PEGylated fluorescent NPs were further used as a labeling agent for KB cells. View Full-Text
Keywords: ATRP; click chemistry; one-pot synthesis; PEGylated; fluorescent nanoparticles; cellular imaging ATRP; click chemistry; one-pot synthesis; PEGylated; fluorescent nanoparticles; cellular imaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xu, L.Q.; Li, N.N.; Zhang, B.; Chen, J.C.; Kang, E.-T. PEGylated Fluorescent Nanoparticles from One-Pot Atom Transfer Radical Polymerization and “Click Chemistry”. Polymers 2015, 7, 2119-2130.

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