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Polymers 2013, 5(3), 1158-1168; doi:10.3390/polym5031158
Article

Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen

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Received: 8 August 2013; in revised form: 2 September 2013 / Accepted: 9 September 2013 / Published: 23 September 2013
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Abstract: Three linear polyesters with pendant ketoprofen were synthesized by copolymerization of polyethylene glycol (PEG) with malic acid (thiomalic acid or aspartic acid) using lipase B acrylic resin from Candida antarctica (CAL-B) at 90 °C respectively. These thermosensitive polyesters exhibit a lower critical solution temperature (LCST) at 10–12 °C. The in vitro study demonstrated that these polyesters could release ketoprofen in neutral and alkaline medium but showed hydrolytic stability in acid medium. These results suggest that, with pendant drugs, these thermosensitive polyesters have potential applications in biomedical materials.
Keywords: enzymatic synthesis; CAL-B; thermosensitive polyester; ketoprofen; PEG enzymatic synthesis; CAL-B; thermosensitive polyester; ketoprofen; PEG
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wu, W.-X.; Wang, H.-Y.; Wang, N.; Zhang, W.-W.; Lai, H.; Yu, X.-Q. Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen. Polymers 2013, 5, 1158-1168.

AMA Style

Wu W-X, Wang H-Y, Wang N, Zhang W-W, Lai H, Yu X-Q. Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen. Polymers. 2013; 5(3):1158-1168.

Chicago/Turabian Style

Wu, Wan-Xia; Wang, Hai-Yang; Wang, Na; Zhang, Wei-Wei; Lai, Han; Yu, Xiao-Qi. 2013. "Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen." Polymers 5, no. 3: 1158-1168.


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