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Polymers 2013, 5(3), 1158-1168; doi:10.3390/polym5031158

Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen

Key Laboratory of Green Chemistry & Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, China
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Received: 8 August 2013 / Revised: 2 September 2013 / Accepted: 9 September 2013 / Published: 23 September 2013
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Abstract

Three linear polyesters with pendant ketoprofen were synthesized by copolymerization of polyethylene glycol (PEG) with malic acid (thiomalic acid or aspartic acid) using lipase B acrylic resin from Candida antarctica (CAL-B) at 90 °C respectively. These thermosensitive polyesters exhibit a lower critical solution temperature (LCST) at 10–12 °C. The in vitro study demonstrated that these polyesters could release ketoprofen in neutral and alkaline medium but showed hydrolytic stability in acid medium. These results suggest that, with pendant drugs, these thermosensitive polyesters have potential applications in biomedical materials.
Keywords: enzymatic synthesis; CAL-B; thermosensitive polyester; ketoprofen; PEG enzymatic synthesis; CAL-B; thermosensitive polyester; ketoprofen; PEG
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wu, W.-X.; Wang, H.-Y.; Wang, N.; Zhang, W.-W.; Lai, H.; Yu, X.-Q. Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen. Polymers 2013, 5, 1158-1168.

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