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Polymers 2012, 4(2), 964-985; doi:10.3390/polym4020964

Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy

Department of Pharmaceutical and Applied Chemistry, University of Siena, Via A. Moro 2, I-53100 Siena, Italy
Author to whom correspondence should be addressed.
Received: 31 January 2012 / Revised: 15 March 2012 / Accepted: 20 March 2012 / Published: 27 March 2012
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A series of homopolymeric and copolymeric hydrogels containing the N-isopropylacrylamide and vinyl monomers with α-amino acid (L-valine and L-phenylalanine) residues have been synthesized and their swelling properties were evaluated under different external stimulations. The hydrogels, obtained with different cross-linking agents (EBA and PEG-DA), have shown unique properties such as biocompatibility in addition to the stimuli-responsive characters. These ‘smart’ hydrogels exhibit single or multiple stimuli-responsiveness which could be used in biomedical applications, including controlled drug delivery. This article focuses on recent developments dealing with the delivery of metal-based drug (cisplatin, lithium) from the stimuli-responsive hydrogels proposed as platforms for cancer and bipolar disorder therapies. View Full-Text
Keywords: stimuli-responsive hydrogels; cisplatin chemotherapy; melanoma cells; lithium; bipolar disorder stimuli-responsive hydrogels; cisplatin chemotherapy; melanoma cells; lithium; bipolar disorder

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Casolaro, M.; Casolaro, I. Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy. Polymers 2012, 4, 964-985.

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