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Synthetic Polymer Scaffolds for Stem Cell Transplantation in Retinal Tissue Engineering
Department of Ophthalmology, Eye & ENT Hospital, Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai 200031, China
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
The Charles Stark Draper Laboratory, Inc., 555 Technology Square, MS37 Cambridge, MA 02139, USA
* Author to whom correspondence should be addressed.
Received: 17 April 2011; in revised form: 23 May 2011 / Accepted: 25 May 2011 / Published: 26 May 2011
Abstract: Age-related macular degeneration and retinitis pigmentosa are two leading causes of irreversible blindness characterized by photoreceptor loss. Cell transplantation may be one of the most promising approaches of retinal repair. However, several problems hinder the success of retinal regeneration, including cell delivery and survival, limited cell integration and incomplete cell differentiation. Recent studies show that polymer scaffolds can address these three problems. This article reviews the current literature on synthetic polymer scaffolds used for stem cell transplantation, especially retinal progenitor cells. The advantages and disadvantages of different polymer scaffolds, the role of different surface modifications on cell attachment and differentiation, and controlled drug delivery are discussed. The development of material and surface modification techniques is vital in making cell transplantation a clinical success.
Keywords: progenitor cell; transplantation; polymer; tissue engineering; retina
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MDPI and ACS Style
Yao, J.; Tao, S.L.; Young, M.J. Synthetic Polymer Scaffolds for Stem Cell Transplantation in Retinal Tissue Engineering. Polymers 2011, 3, 899-914.
Yao J, Tao SL, Young MJ. Synthetic Polymer Scaffolds for Stem Cell Transplantation in Retinal Tissue Engineering. Polymers. 2011; 3(2):899-914.
Yao, Jing; Tao, Sarah L.; Young, Michael J. 2011. "Synthetic Polymer Scaffolds for Stem Cell Transplantation in Retinal Tissue Engineering." Polymers 3, no. 2: 899-914.