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Polymers 2018, 10(8), 914; https://doi.org/10.3390/polym10080914

Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects

1
School of Chemical and Biological Engineering, the Institute of Chemical Processes, Seoul National University, Seoul 08826, Korea
2
Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Korea
3
Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi 682041, India
4
Department of Otorhinolaryngology—Head and Neck Surgery, Seoul National University Hospital, Seoul 03080, Korea
5
BioMAX/N-Bio Institute, Seoul National University, Seoul 08826, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 12 July 2018 / Revised: 9 August 2018 / Accepted: 10 August 2018 / Published: 14 August 2018
(This article belongs to the Special Issue Polymeric Micro/Nanoparticles for Bio-Medical Applications)
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Abstract

Cryogels have recently gained interest in the field of tissue engineering as they inherently possess an interconnected macroporous structure. Considered to be suitable for scaffold cryogel fabrication, methacrylated gelatin (GelMA) is a modified form of gelatin valued for its ability to retain cell adhesion site. Bioglass nanoparticles have also attracted attention in the field due to their osteoinductive and osteoconductive behavior. Here, we prepare methacrylated gelatin cryogel with varying concentration of bioglass nanoparticles to study its potential for bone regeneration. We demonstrate that an increase in bioglass concentration in cryogel leads to improved mechanical property and augmented osteogenic differentiation of mesenchymal cells during in vitro testing. Furthermore, in vivo testing in mice cranial defect model shows that highest concentration of bioglass nanoparticles (2.5 w/w %) incorporated in GelMA cryogel induces the most bone formation compared to the other tested groups, as studied by micro-CT and histology. The in vitro and in vivo results highlight the potential of bioglass nanoparticles incorporated in GelMA cryogel for bone regeneration. View Full-Text
Keywords: methacrylated gelatin; bioglass; hydrogel; cryogel; bone tissue engineering methacrylated gelatin; bioglass; hydrogel; cryogel; bone tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kwon, S.; Lee, S.S.; Sivashanmugam, A.; Kwon, J.; Kim, S.H.L.; Noh, M.Y.; Kwon, S.K.; Jayakumar, R.; Hwang, N.S. Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects. Polymers 2018, 10, 914.

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