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Polymers 2018, 10(7), 772; https://doi.org/10.3390/polym10070772

Development of Poly(HEMA-Am) Polymer Hydrogel Filler for Soft Tissue Reconstruction by Facile Polymerization

1
Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Korea
2
Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul 03080, Korea
3
Department of Research Administration Team, Seoul National University, Bundang Hospital, Seongnam 13620, Korea
4
Interdisciplinary Program for Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Korea
5
Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Korea
6
Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03087, Korea
7
Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Korea
8
Advanced Institutes of Convergence Technology, Gyeonggi-do 16229, Korea
*
Authors to whom correspondence should be addressed.
Received: 1 June 2018 / Revised: 6 July 2018 / Accepted: 11 July 2018 / Published: 13 July 2018
(This article belongs to the Special Issue Polymer Scaffolds for Biomedical Application)
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Abstract

The number of breast reconstruction surgeries has been increasing due to the increase in mastectomies. Surgical implants (the standard polydimethylsiloxane (PDMS) implants) are widely used to reconstruct breast tissues, however, it can cause problems such as adverse immune reactions, fibrosis, rupture, and additional surgery. Hence, polymeric fillers have recently garnered increasing attention as strong alternatives for breast reconstruction materials. Polymeric fillers offer noninvasive methods of reconstruction, thereby reducing the possible adverse effects and simplifying the treatment. In this study, we synthesized a 2-hydroxylethylmethacrylate (HEMA) and acrylamide (Am) copolymer (Poly(HEMA-Am)) by redox polymerization to be used as a biocompatible filler material for breast reconstruction. The synthesized hydrogel swelled in phosphate buffered saline (PBS) shows an average modulus of 50 Pa, which is a characteristic similar to that of the standard dermal acrylamide filler. To investigate the biocompatibility and cytotoxicity of the Poly(HEMA-Am) hydrogel, we evaluated an in vitro cytotoxicity assay on human fibroblasts (hFBs) and human adipose-derived stem cells (hADSCs) with the hydrogel eluate, and confirmed a cell viability of over 80% of the cell viability with the Poly(HEMA-Am) hydrogel. These results suggest our polymeric hydrogel is a promising filler material in soft tissue augmentation including breast reconstruction. View Full-Text
Keywords: Poly(HEMA-Am), hydrogel; soft tissue filler; soft tissue reconstruction Poly(HEMA-Am), hydrogel; soft tissue filler; soft tissue reconstruction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Kim, S.; Shin, B.H.; Yang, C.; Jeong, S.; Shim, J.H.; Park, M.H.; Choy, Y.B.; Heo, C.Y.; Lee, K. Development of Poly(HEMA-Am) Polymer Hydrogel Filler for Soft Tissue Reconstruction by Facile Polymerization. Polymers 2018, 10, 772.

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