Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery
AbstractHypoxia, or low oxygen tension, is a common feature of solid tumors. Here, we report hypoxia-responsive mesoporous silica nanoparticles (HR-MSNs) with a 4-nitroimidazole-β-cyclodextrin (NI-CD) complex that is acting as the hypoxia-responsive gatekeeper. When these CD-HR-MSNs encountered a hypoxic environment, the nitroimidazole (NI) gatekeeper portion of CD-HR-MSNs disintegrated through bioreduction of the hydrophobic NI state to the hydrophilic NI state. Under hypoxic conditions, the release rate of doxorubicin (DOX) from DOX-loaded CD-HR-MSNs (DOX-CD-HR-MSNs) increased along with the disintegration of the gatekeeper. Conversely, DOX release was retarded under normoxic conditions. In vitro experiments confirmed that DOX-CD-HR-MSNs exhibit higher toxicity to hypoxic cells when compared to normoxic cells. Confocal microscopy images indicated that DOX-CD-HR-MSNs effectively release DOX into SCC-7 cells under hypoxic conditions. These results demonstrate that CD-HR-MSNs can release drugs in a hypoxia-responsive manner, and thus are promising drug carriers for hypoxia-targeted cancer therapy. View Full-Text
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Khatoon, S.; Han, H.S.; Jeon, J.; Rao, N.V.; Jeong, D.-W.; Ikram, M.; Yasin, T.; Yi, G.-R.; Park, J.H. Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery. Polymers 2018, 10, 390.
Khatoon S, Han HS, Jeon J, Rao NV, Jeong D-W, Ikram M, Yasin T, Yi G-R, Park JH. Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery. Polymers. 2018; 10(4):390.Chicago/Turabian Style
Khatoon, Shakera; Han, Hwa S.; Jeon, Jueun; Rao, N. V.; Jeong, Dae-Woong; Ikram, M.; Yasin, T.; Yi, Gi-Ra; Park, Jae H. 2018. "Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery." Polymers 10, no. 4: 390.
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