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Polymers 2018, 10(3), 273; doi:10.3390/polym10030273

The Anomalies of Hyaluronan Structures in Presence of Surface Active Phospholipids—Molecular Mass Dependence

Institute of Mathematics and Physics, UTP University of Science and Technology, 85-796 Bydgoszcz, Poland
Faculty of Telecommunications, Computer Science and Technology, UTP University of Science and Technology, 85-796 Bydgoszcz, Poland
Faculty of Technology, Kujawy and Pomorze University in Bydgoszcz, Toruńska 55-57, 85-023 Bydgoszcz, Poland
University of Economy, Biotribology Laboratory, Garbary 2, 85-229 Bydgoszcz, Poland
Tribochemistry Consulting, Salt Lake City, UT 84117, USA
Department of Research and Development, NuOrtho Surgical, Inc., Boston, MA 02723, USA
Author to whom correspondence should be addressed.
Received: 1 February 2018 / Revised: 2 March 2018 / Accepted: 4 March 2018 / Published: 6 March 2018
(This article belongs to the Special Issue Mechanics of Emerging Polymers with Unprecedented Networks)
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Interactions between hyaluronan (A-) and phospholipids play a key role in many systems in the human body. One example is the articular cartilage system, where the synergistic effect of such interactions supports nanoscale lubrication. A molecular dynamics simulation has been performed to understand the process of formation of hydrogen bonds inside the hyaluronan network, both in the presence and absence of phospholipids. Additionally, the effect of the molecular mass of (A-) was analyzed. The main finding of this work is a robust demonstration of the optimal parameters (H-bond energy, molecular mass) influencing the facilitated lubrication mechanism of the articular cartilage system. Simulation results show that the presence of phospholipids has the greatest influence on hyaluronan at low molecular mass. We also show the specific sites of H-bonding between chains. Simulation results can help to understand how hyaluronan and phospholipids interact at several levels of articular cartilage system functioning. View Full-Text
Keywords: hyaluronan (A-); phospholipid; articular cartilage hyaluronan (A-); phospholipid; articular cartilage

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bełdowski, P.; Andrysiak, T.; Mreła, A.; Pawlak, Z.; Augé, W.K., II; Gadomski, A. The Anomalies of Hyaluronan Structures in Presence of Surface Active Phospholipids—Molecular Mass Dependence. Polymers 2018, 10, 273.

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