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Polymers 2018, 10(1), 14; https://doi.org/10.3390/polym10010014

PLMA-b-POEGMA Amphiphilic Block Copolymers as Nanocarriers for the Encapsulation of Magnetic Nanoparticles and Indomethacin

1
Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece
2
Department of Pharmacy, University of Patras, 26504 Rio Patras, Greece
3
Department of Materials Science, University of Patras, 25604 Rio Patras, Greece
4
UCL Healthcare Biomagnetic and Nanomaterials Laboratories, Department of Physics and Astronomy, The Royal Institution of Great Britain, 21 Albemarle street, London W1S 4BS, UK
5
Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 24 November 2017 / Revised: 15 December 2017 / Accepted: 20 December 2017 / Published: 23 December 2017
(This article belongs to the Special Issue Polymer Micelles)
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Abstract

We report here on the utilization of poly(lauryl methacrylate)-b-poly(oligo ethylene glycol methacrylate) (PLMA-b-POEGMA) amphiphilic block copolymers, which form compound micelles in aqueous solutions, as nanocarriers for the encapsulation of either magnetic iron oxide nanoparticles or iron oxide nanoparticles, and the model hydrophobic drug indomethacin in the their hydrophobic core. The mixed nanostructures were characterized using dynamic light scattering (DLS) and transmission electron microscopy (TEM) in terms of their structure and solution properties. Magnetophoresis experiments showed that the mixed solutions maintain the magnetic properties of the initial iron oxide nanoparticles. Results indicate that the cumulative hydrophilic/hydrophobic balance of all components determines the colloidal stability of the nanosystems. The effect of salt and bovine serum albumin (BSA) protein concentration on the structure of the mixed nanostructures was also investigated. Disintegration of the mixed nanostructures was observed in both cases, showing the importance of these parameters in the structure formation and stability of such complex mixed nanosystems. View Full-Text
Keywords: amphiphilic block copolymers; micelles; self-assembly; encapsulation; magnetic nanoparticles; indomethacin amphiphilic block copolymers; micelles; self-assembly; encapsulation; magnetic nanoparticles; indomethacin
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Skandalis, A.; Sergides, A.; Bakandritsos, A.; Pispas, S. PLMA-b-POEGMA Amphiphilic Block Copolymers as Nanocarriers for the Encapsulation of Magnetic Nanoparticles and Indomethacin. Polymers 2018, 10, 14.

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