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Crystals 2012, 2(3), 1058-1066; doi:10.3390/cryst2031058
Article

Crystal and Molecular Structures of Two 2-Aminothiophene Derivatives

1,* , 1
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2
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3
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3
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2
Received: 29 February 2012 / Revised: 10 July 2012 / Accepted: 11 July 2012 / Published: 27 July 2012
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Abstract

The crystal and molecular structures of two 2-aminothiophene derivatives, potential allosteric enhancers at the human A1 adenosine receptor, are reported. (2-Amino-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)(phenyl)methanone (1) crystallizes in the orthorhombic space group Pna21 (a = 9.2080(4) Å, b = 14.0485(7) Å, c = 10.3826(6) Å), and (2-amino-5-ethylthiophen-3-yl)(2-chlorophenyl)methanone (2) crystalizes in the monoclinic P21/c space group with unit cell parameters a = 10.6092(8) Å, b = 10.8355(8) Å, c = 11.1346(9) Å, β = 98.643(6)Å. In both molecules the intramolecular N–H···O=C hydrogen bonds close six-membered planar rings and significantly influence the molecular conformation. Intermolecular N–H···O bonds connect the molecules in infinite chains along a in case of 1, and along b in 2; in each case the appropriate unit cell axis is approximately 10 Å long.
Keywords: 2-aminothiophenes; crystal structure; conformation; hydrogen bonds; weak interactions 2-aminothiophenes; crystal structure; conformation; hydrogen bonds; weak interactions
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kubicki, M.; Dutkiewicz, G.; Yathirajan, H.S.; Dawar, P.; Ramesha, A.R.; Dayananda, A.S. Crystal and Molecular Structures of Two 2-Aminothiophene Derivatives. Crystals 2012, 2, 1058-1066.

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