Next Article in Journal
Photoinduced Phase Transition in Strongly Electron-Lattice and Electron–Electron Correlated Molecular Crystals
Previous Article in Journal
Magnetic and Electric Properties of Organic Conductors Probed by 13C-NMR Using Selective-Site Substituted Molecules
Crystals 2012, 2(3), 1058-1066; doi:10.3390/cryst2031058
Article

Crystal and Molecular Structures of Two 2-Aminothiophene Derivatives

1,* , 1
,
2
,
3
,
3
 and
2
1 Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland 2 Department of Studies in Chemistry, University of Mysore, Mysore 570 006, India 3 R. L. Fine Chem, No. 15, KHB Industrial area, Yelahanka New Town, Bengaluru 560 106, India
* Author to whom correspondence should be addressed.
Received: 29 February 2012 / Revised: 10 July 2012 / Accepted: 11 July 2012 / Published: 27 July 2012
View Full-Text   |   Download PDF [309 KB, 31 July 2012; original version 27 July 2012]   |  

Abstract

The crystal and molecular structures of two 2-aminothiophene derivatives, potential allosteric enhancers at the human A1 adenosine receptor, are reported. (2-Amino-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)(phenyl)methanone (1) crystallizes in the orthorhombic space group Pna21 (a = 9.2080(4) Å, b = 14.0485(7) Å, c = 10.3826(6) Å), and (2-amino-5-ethylthiophen-3-yl)(2-chlorophenyl)methanone (2) crystalizes in the monoclinic P21/c space group with unit cell parameters a = 10.6092(8) Å, b = 10.8355(8) Å, c = 11.1346(9) Å, β = 98.643(6)Å. In both molecules the intramolecular N–H···O=C hydrogen bonds close six-membered planar rings and significantly influence the molecular conformation. Intermolecular N–H···O bonds connect the molecules in infinite chains along a in case of 1, and along b in 2; in each case the appropriate unit cell axis is approximately 10 Å long.
Keywords: 2-aminothiophenes; crystal structure; conformation; hydrogen bonds; weak interactions 2-aminothiophenes; crystal structure; conformation; hydrogen bonds; weak interactions
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Kubicki, M.; Dutkiewicz, G.; Yathirajan, H.S.; Dawar, P.; Ramesha, A.R.; Dayananda, A.S. Crystal and Molecular Structures of Two 2-Aminothiophene Derivatives. Crystals 2012, 2, 1058-1066.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Crystals EISSN 2073-4352 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert