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Pharmaceutics 2017, 9(4), 38; doi:10.3390/pharmaceutics9040038

The Development of a Melt-Extruded Shellac Carrier for the Targeted Delivery of Probiotics to the Colon

1
Materials Research Institute, Athlone Institute of Technology, Co. Westmeath N37 HD68, Ireland
2
Centre for Industrial Services and Design (CISD), Department of Mechanical and Polymer Engineering, School of Engineering, Athlone Institute of Technology, Co. Westmeath N37 HD68, Ireland
*
Author to whom correspondence should be addressed.
Received: 24 July 2017 / Revised: 14 September 2017 / Accepted: 17 September 2017 / Published: 22 September 2017
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Abstract

Hot melt extrusion (HME) is considered an efficient technique in developing solid molecular dispersions, and has been demonstrated to provide sustained, modified and targeted drug delivery resulting in improved bioavailability. However, most commercial enteric or pH-responsive polymers are relatively difficult to process or have high Glass Transition Temperature (Tg) values, making their use with temperature-sensitive drugs, probiotics or biologics not viable. Shellac is a natural thermoplastic, and after a review of current literature on the pharmaceutical HME process, a possible gap in the knowledge of the use of shellac to produce dosage forms by means of HME was identified. This work explores the possibility of SSB® 55 pharmaceutical-grade shellac as a melt-extrudable encapsulation polymer to entrap freeze-dried probiotic powder and to determine bacterial cell viability post-processing. Well-defined strands were produced from the physical mixture of shellac and Biocare® Bifidobacterium Probiotic. FTIR clarified that there are no significant interactions between the probiotic and polymer. All of the samples demonstrated less than 5% degradation over 24 h at pH of both 1.2 and 6.8. At pH 7.4, both loaded samples gave a similar dissolution trend with complete degradation achieved after 10–11 h. Following five-month storage, 57.8% reduction in viability was observed. View Full-Text
Keywords: therapeutic delivery; shellac; probiotics; melt extrusion therapeutic delivery; shellac; probiotics; melt extrusion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gately, N.M.; Kennedy, J.E. The Development of a Melt-Extruded Shellac Carrier for the Targeted Delivery of Probiotics to the Colon. Pharmaceutics 2017, 9, 38.

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