Next Article in Journal
Optimization of a siRNA Carrier Modified with a pH-Sensitive Cationic Lipid and a Cyclic RGD Peptide for Efficiently Targeting Tumor Endothelial Cells
Previous Article in Journal
Topical Anti-Nuclear Factor-Kappa B Small Interfering RNA with Functional Peptides Containing Sericin-Based Hydrogel for Atopic Dermatitis
Article Menu

Export Article

Open AccessArticle
Pharmaceutics 2015, 7(3), 305-319; doi:10.3390/pharmaceutics7030305

Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

Department of Pharmacy Health and Wellbeing, Faculty of Applied Sciences, University of Sunderland, Science Complex, Wharncliffe Street, SR1 3SD Sunderland, UK
Part of the data was presented at the 42nd Annual Meeting & Exposition of the Controlled Release Society in Edinburgh, Scotland, 2015.
*
Author to whom correspondence should be addressed.
Academic Editor: Afzal R. Mohammed
Received: 9 June 2015 / Revised: 27 August 2015 / Accepted: 1 September 2015 / Published: 9 September 2015
View Full-Text   |   Download PDF [2711 KB, uploaded 9 September 2015]   |  

Abstract

Novel polyethylene oxide (PEO) hydrogel films were synthesized via UV crosslinking with varying concentrations of pentaerythritol tetra-acrylate (PETRA) as crosslinking agent. The aim was to study the effects of the crosslinking agent on the material properties of hydrogel films intended for dermatological applications. Fabricated film samples were characterized using swelling studies, scanning electron microscopy, tensile testing and rheometry. Films showed rapid swelling and high elasticity. The increase of PETRA concentration resulted in significant increase in the gel fraction and crosslinking density (ρc), while causing a significant decrease in the equilibrium water content (EWC), average molecular weight between crosslinks (\({\overline{M}}_{c}\)), and mesh size (ζ) of films. From the scanning electron microscopy, cross-linked PEO hydrogel network appeared as cross-linked mesh-like structure with interconnected micropores. Rheological studies showed PEO films required a minimum of 2.5% w/w PETRA to form stable viscoelastic solid gels. Preliminary studies concluded that a minimum of 2.5% w/w PETRA is required to yield films with desirable properties for skin application. View Full-Text
Keywords: poly(ethylene oxide) (PEO); pentaerythritol tetraacrylate (PETRA); gel; transdermal; ultraviolet radiation; scanning electron microscopy; tensile strength; viscoelasticity poly(ethylene oxide) (PEO); pentaerythritol tetraacrylate (PETRA); gel; transdermal; ultraviolet radiation; scanning electron microscopy; tensile strength; viscoelasticity
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wong, R.S.H.; Ashton, M.; Dodou, K. Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels. Pharmaceutics 2015, 7, 305-319.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top