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Pharmaceutics 2015, 7(2), 43-63; doi:10.3390/pharmaceutics7020043

Product Development Studies on Sonocrystallized Curcumin for the Treatment of Gastric Cancer

Department of Pharmaceutics, Rajiv Academy for Pharmacy, N.H. #2, Delhi Mathura Road, P.O. Chhattikara, Mathura-281001, India
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Academic Editor: Axel Zeitler
Received: 18 February 2015 / Revised: 15 April 2015 / Accepted: 15 April 2015 / Published: 27 April 2015
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Abstract

Curcumin suffers from the limitation of poor solubility and low dissolution that can lead to limited applications. The investigation was aimed to substantiate the potentiality of melt sonocrystallized gastroretentive tablets of curcumin. Melt sonocrystallized curcumin (MSC CMN) was developed and its therapeutic potential was validated by in vitro cytotoxicity studies against Human oral cancer cell line KB. MSC curcumin was then formulated as floating tablet and evaluated. MSC form of CMN exhibited 2.36-fold and 2.40-fold solubility enhancement in distilled water and phosphate buffer, pH 4.5, respectively, better flow properties and intrinsic dissolution rate (0.242 ± 1.42 and 0.195 ± 1.26 mg/cm2/min) in comparison to its original form. The GI50 value of MSC CMN was found to be less than 10, specifying inhibition of growth more effectively at its least concentration by 50%. The gastroretentive-floating tablet (Formulation F4) displayed controlled drug release (96.22% ± 1.43%) for over 12 h. The present study revealed melt sonocrystallization can be used to produce particles with superior biopharmaceutical properties without the use of organic solvents or the addition of other excipients, and amenable to formulation in to a pharmaceutical dosage form. View Full-Text
Keywords: curcumin; melt sonocrystallization; spectral characterization; in vitro cytotoxicity; gastroretentive floating tablet curcumin; melt sonocrystallization; spectral characterization; in vitro cytotoxicity; gastroretentive floating tablet
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Khan, M.A.; Akhtar, N.; Sharma, V.; Pathak, K. Product Development Studies on Sonocrystallized Curcumin for the Treatment of Gastric Cancer. Pharmaceutics 2015, 7, 43-63.

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