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Pharmaceutics 2013, 5(1), 107-114; doi:10.3390/pharmaceutics5010107

Steroid Nanocrystals Prepared Using the Nano Spray Dryer B-90

Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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Received: 10 October 2012 / Revised: 15 January 2013 / Accepted: 21 January 2013 / Published: 25 January 2013
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Abstract

The Nano Spray Dryer B-90 offers a new, simple, and alternative approach for the production of drug nanocrystals. In this study, the preparation of steroid nanocrystals using the Nano Spray Dryer B-90 was demonstrated. The particle size was controlled by selecting the mesh aperture size. Submicrometer steroid particles in powder form were successfully obtained. These nanoparticles were confirmed to have a crystal structure using powder X-ray diffraction pattern analysis. Since drug nanocrystals have recently been considered as a novel type of drug formulation for drug delivery systems, this study will be useful for nano-medical applications. View Full-Text
Keywords: steroid; fluorometholone; dexamethasone; drug nanocrystals; Nano Spray Dryer B-90 steroid; fluorometholone; dexamethasone; drug nanocrystals; Nano Spray Dryer B-90
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Baba, K.; Nishida, K. Steroid Nanocrystals Prepared Using the Nano Spray Dryer B-90. Pharmaceutics 2013, 5, 107-114.

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