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Steroid Nanocrystals Prepared Using the Nano Spray Dryer B-90
Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
* Author to whom correspondence should be addressed.
Received: 10 October 2012; in revised form: 15 January 2013 / Accepted: 21 January 2013 / Published: 25 January 2013
Abstract: The Nano Spray Dryer B-90 offers a new, simple, and alternative approach for the production of drug nanocrystals. In this study, the preparation of steroid nanocrystals using the Nano Spray Dryer B-90 was demonstrated. The particle size was controlled by selecting the mesh aperture size. Submicrometer steroid particles in powder form were successfully obtained. These nanoparticles were confirmed to have a crystal structure using powder X-ray diffraction pattern analysis. Since drug nanocrystals have recently been considered as a novel type of drug formulation for drug delivery systems, this study will be useful for nano-medical applications.
Keywords: steroid; fluorometholone; dexamethasone; drug nanocrystals; Nano Spray Dryer B-90
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MDPI and ACS Style
Baba, K.; Nishida, K. Steroid Nanocrystals Prepared Using the Nano Spray Dryer B-90. Pharmaceutics 2013, 5, 107-114.
Baba K, Nishida K. Steroid Nanocrystals Prepared Using the Nano Spray Dryer B-90. Pharmaceutics. 2013; 5(1):107-114.
Baba, Koichi; Nishida, Kohji. 2013. "Steroid Nanocrystals Prepared Using the Nano Spray Dryer B-90." Pharmaceutics 5, no. 1: 107-114.