Compaction Behavior of Isomalt after Roll Compaction
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Methods
2.2.1. Roll Compaction
2.2.2. Analysis of Powders and Granules
2.2.3. Tableting and Characterization of Tablets
2.2.4. Nomenclature
Granules (G) or tablets (T)-isomalt (A) or isomalt-DCP (B)-specific compaction force (kN/cm)_tableting force (kN) (if tableted)
3. Results and discussion
3.1. Characterization of Granules
Specific compaction force [kN/cm] | Isomalt granules | Isomalt-DCP granules | |||||||
---|---|---|---|---|---|---|---|---|---|
0 | 2 | 6 | 10 | 14 | 0 | 6 | 10 | 14 | |
Hausner factor | 1.33 | 1.21 | 1.16 | 1.15 | 1.11 | 1.44 | 1.24 | 1.15 | 1.15 |
ffc value | 3.6 | 6.8 | 12.1 | 16.6 | 16.5 | 3.2 | 4.8 | 10.1 | 8.4 |
x10 [µm] | 1.7 | 25.0 | 141.5 | 184.0 | 186.5 | 1.0 | 36.6 | 37.5 | 41.0 |
x50 [µm] | 17.7 | 546 | 642 | 607 | 617 | 7.2 | 556 | 590 | 554 |
x90 [µm] | 44.6 | 923 | 934 | 921 | 938 | 31.1 | 920 | 927 | 928 |
3.2. Characterization of Tablets
2.0 kN/cm | 6.0 kN/cm | 10.0 kN/cm | 14.0 kN/cm | |
---|---|---|---|---|
3 kN | not passed | not passed | not passed | not passed |
6 kN | not passed | not passed | not passed | not passed |
9 kN | not passed | 0.91% | not passed | not passed |
12 kN | 0.62% | 0.75% | not passed | not passed |
15 kN | 0.74% | 0.60% | not passed | not passed |
4. Conclusion
Acknowledgments
Conflict of Interest
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Quodbach, J.; Mosig, J.; Kleinebudde, P. Compaction Behavior of Isomalt after Roll Compaction. Pharmaceutics 2012, 4, 494-500. https://doi.org/10.3390/pharmaceutics4040494
Quodbach J, Mosig J, Kleinebudde P. Compaction Behavior of Isomalt after Roll Compaction. Pharmaceutics. 2012; 4(4):494-500. https://doi.org/10.3390/pharmaceutics4040494
Chicago/Turabian StyleQuodbach, Julian, Johanna Mosig, and Peter Kleinebudde. 2012. "Compaction Behavior of Isomalt after Roll Compaction" Pharmaceutics 4, no. 4: 494-500. https://doi.org/10.3390/pharmaceutics4040494