Pharmaceutics 2012, 4(1), 197-211; doi:10.3390/pharmaceutics4010197
Review

Ocular Drug Delivery for Glaucoma Management

Nathan Gooch 1 , Sarah A. Molokhia 2 , Russell Condie 1 , Randon Michael Burr 3 , Bonnie Archer 3 , Balamurali K. Ambati 3  and Barbara Wirostko 3,* email
1 Department of Bioengineering, University of Utah, Salt Lake City, UT, USA 2 Department of Pharmacy, University of Utah, Salt Lake City, UT, USA 3 Moran Eye Center, University of Utah, Salt Lake City, UT, USA
* Author to whom correspondence should be addressed.
Received: 22 December 2011; in revised form: 6 February 2012 / Accepted: 1 March 2012 / Published: 8 March 2012
(This article belongs to the Special Issue Ocular Drug Delivery)
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Abstract: Current glaucoma management modalities are hindered by low patient compliance and adherence. This can be due to highly complex treatment strategies or poor patient understanding. Treatments focus on the management or reduction of intraocular pressure. This is most commonly done through the use of daily topical eye drops. Unfortunately, despite effective therapies, glaucoma continues to progress, possibly due to patients not adhering to their treatments. In order to mitigate these patient compliance issues, many sustained release treatments are being researched and are entering the clinic. Conjunctival, subconjunctival, and intravitreal inserts, punctal plugs, and drug depots are currently in clinical development. Each delivery system has hurdles, yet shows promise and could potentially mitigate the current problems associated with poor patient compliance.
Keywords: glaucoma; IOP; drug delivery; sustained release; polymer; inserts; punctal plug

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Cite This Article

MDPI and ACS Style

Gooch, N.; Molokhia, S.A.; Condie, R.; Burr, R.M.; Archer, B.; Ambati, B.K.; Wirostko, B. Ocular Drug Delivery for Glaucoma Management. Pharmaceutics 2012, 4, 197-211.

AMA Style

Gooch N, Molokhia SA, Condie R, Burr RM, Archer B, Ambati BK, Wirostko B. Ocular Drug Delivery for Glaucoma Management. Pharmaceutics. 2012; 4(1):197-211.

Chicago/Turabian Style

Gooch, Nathan; Molokhia, Sarah A.; Condie, Russell; Burr, Randon Michael; Archer, Bonnie; Ambati, Balamurali K.; Wirostko, Barbara. 2012. "Ocular Drug Delivery for Glaucoma Management." Pharmaceutics 4, no. 1: 197-211.

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