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• Sandler, N
• Reiche, K
• Heinämäki, J
• Yliruusi, J
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• Reiche, K
• Heinämäki, J
• Yliruusi, J
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• Reiche, K
• Heinämäki, J
• Yliruusi, J

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Pharmaceutics 2010, 2(3), 275-290; doi:10.3390/pharmaceutics2030275

Article

Effect of Moisture on Powder Flow Properties of Theophylline

Niklas Sandler ^1,* , Katharina Reiche ² , Jyrki Heinämäki ²  and Jouko Yliruusi ²

¹ Pharmaceutical Sciences, Department of Biosciences, Åbo Akademi University, Turku, Finland ² Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Finland

* Author to whom correspondence should be addressed.

Received: 19 May 2010; in revised form: 24 June 2010 / Accepted: 30 June 2010 / Published: 2 July 2010

(This article belongs to the Special Issue Current Trends in Dosage Form Development)

Download PDF Full-Text [1672 KB, uploaded 2 July 2010 09:17 CEST]

Abstract: Powder flow is influenced by environmental factors, such as moisture and static electricity, as well as powder related factors, such as morphology, size, size distribution, density, and surface area. Pharmaceutical solids may be exposed to water during storage in an atmosphere containing water vapor, or in a dosage form consisting of materials (e.g., excipients) that contain water and are capable of transferring in to other ingredients. The effect of moisture on powder flowability depends on the amount of water and its distribution. The aim of this work was to examine the effect of humidity on the flow properties of theophylline using information derived from solid-state analysis of the systems investigated.

Keywords: powder flow; relative humidity; equilibrium moisture content; solid-state properties; theophylline

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