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Assessment of Thermal Transitions by Dynamic Mechanical Analysis (DMA) Using a Novel Disposable Powder Holder
Department of Agricultural and Biological Engineering and Whistler Carbohydrate Research Center, Purdue University, 225 S. University St., West Lafayette, IN 47907, USA
Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907, USA
Present address: Department of Nutrition and Food Science, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut 1107-2020, Lebanon.
* Author to whom correspondence should be addressed.
Received: 8 February 2010; in revised form: 11 March 2010 / Accepted: 18 March 2010 / Published: 24 March 2010
Abstract: Foods and pharmaceuticals materials are exposed to various environmental conditions during processing and while in storage; therefore, stability and quality are key attributes of concern. The properties of foods and pharmaceutical materials that define their quality are affected by conditions such as temperature, humidity and time. Glass transition is considered a key material property to understand how these external conditions affect the stability and quality of foods and pharmaceuticals. Thus, investigating the thermo-mechanical properties of these materials as well as characterizing the glass transition temperature have a great interest not only in the food industry, but also extend to the pharmaceutical and polymer industries. The aim of this study was to design and test a new disposable powder holder that allows the use of a dynamic mechanical analysis (DMA) instrument to test and characterize loose powder samples. The disposable aluminum powder holder was designed and constructed to be used in the single cantilever configuration on a TA Instruments RSA III DMA. Three different powder samples – Felodipine, polyethylene-oxide (MW 900 kDa) and HPMC (E4M) – were used for validation. The use of this powder holder allows the detection of different thermal changes of powder samples without compacting and when large sample size is necessary for detection and/or interpretation.
Keywords: amorphous powders; glass transition; dynamic mechanical analysis (DMA); powder holder; HPMC; polyethylene oxide; Felodipine
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Abiad, M.G.; Campanella, O.H.; Carvajal, M.T. Assessment of Thermal Transitions by Dynamic Mechanical Analysis (DMA) Using a Novel Disposable Powder Holder. Pharmaceutics 2010, 2, 78-90.
Abiad MG, Campanella OH, Carvajal MT. Assessment of Thermal Transitions by Dynamic Mechanical Analysis (DMA) Using a Novel Disposable Powder Holder. Pharmaceutics. 2010; 2(2):78-90.
Abiad, Mohamad G.; Campanella, Osvaldo H.; Carvajal, M. Teresa. 2010. "Assessment of Thermal Transitions by Dynamic Mechanical Analysis (DMA) Using a Novel Disposable Powder Holder." Pharmaceutics 2, no. 2: 78-90.