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Pharmaceutics 2010, 2(2), 136-158; doi:10.3390/pharmaceutics2020136

Article

Diclofenac Salts. V. Examples of Polymorphism among Diclofenac Salts with Alkyl-hydroxy Amines Studied by DSC and HSM

Adamo Fini ^1,* , Cristina Cavallari ²  and Francesca Ospitali ³

¹ Department SMETEC, University of Bologna, Bologna, Italy ² Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy ³ Department of Inorganic and Physical Chemistry, University of Bologna, Bologna, Italy

* Author to whom correspondence should be addressed.

Received: 30 March 2010; in revised form: 13 April 2010 / Accepted: 22 April 2010 / Published: 27 April 2010

(This article belongs to the Special Issue What's on Board in Pharmaceutics)

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Abstract: Nine diclofenac salts prepared with alkyl-hydroxy amines were analyzed for their properties to form polymorphs by DSC and HSM techniques. Thermograms of the forms prepared from water or acetone are different in most cases, suggesting frequent examples of polymorphism among these salts. Polymorph transition can be better highlighted when analysis is carried out by thermo-microscopy, which in most cases made it possible to observe the processes of melting of the metastable form and re-crystallization of the stable one. Solubility values were qualitatively related to the crystal structure of the salts and the molecular structure of the cation.

Keywords: Diclofenac salts; alkyl-hydroxy amines; polymorphism; DSC/HSM; solubility

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