Drug Solubility Enhancement through the Preparation of Multicomponent Organic Materials: Eutectics of Lovastatin with Carboxylic Acids
, José Roberto Vega-Baudrit 1,4, Teodolito Guillén-Girón 2, Mirtha Navarro-Hoyos 3 and Silvia Lucia Cuffini 5,*Round 1
Reviewer 1 Report
Comments attached
Comments for author File: 
Comments.pdf
Author Response
The response is attached in the document
Author Response File: Author Response.pdf
Reviewer 2 Report
Attached
Comments for author File: Comments.pdf
Author Response
The response is the attached document
Author Response File: Author Response.pdf
Reviewer 3 Report
I recommend to proofread the manuscript by native english speakers since there is a prevalence of spelling and grammatical errors that needs to be addressed.
On the other hand, the authors should include information about wether cocrystallization experiments between lovastatin and the three carboxylic acids have been conducted, or not.
The authors must explain what does "the best thermograms" mean in page 13. Best in terms of what?
Other issues must be addresses before the manuscript be suitable for publication:
In page 1, line 39. Change "the formation occurred" to "the formation of eutectics occurs".
In page 1, line 41. Change "pi-pi interactions" to "aromatic interactions"
In page 1, line 4. Change "Van der Waals" to "van der Waals"
In page 2, line 47. Change "similar to occur" to "similar as it occurs"
In page 2, line 52. The "because" at the start of the sentence sounds weird.
In page 2, line 55. Change "doesn't required" to "does not require" and change "conformer" to "coformer"
In page 2, line 86. Change "conformer" to "coformer"
In page 5, line 182. Change "techniques" to "technique" and change "hence, was applied" to "hence, it was applied"
In page 6, line 201. Remove [38] at the start of the sentence.
In page 6, line 204. Remove "several"
In page 10, line 228 the authors say that "the non-covalent interactions expected for eutectic systems are not strong enough to form new chemical entities". This is not completely true since this statement ignores that other effects such as packing are also important in order to form a new cocrystal. Strong interactions in solution not always produce new multicomponent solid forms.
In page 12, line 267. Change "determined" to "confirmed"
In page 12, line 274. Change "show" to "shown"
In page 14, line 289. Change "are presented the results" to "results are presented"
In page 14, line 307. Change "dicarboxylic acids benzoic..." to "dicarboxylic acids"
In page 14, line 312. The sentence seems uncompleted.
Author Response
The response is in the attached document
Author Response File: Author Response.pdf
Reviewer 4 Report
This manuscript shows an interesting contribution in regards to the solubility improvement in eutectic mixtures of lovastatin.
The authors should provide data on dissolution rate of these systems, as it would complete the study together with the solubility data that is already provided in the manuscript.
I would recommend its publication with minor modifications which include improving the english level in the text and providing dissolution rate measurements.
Author Response
The response is in the attached document
Author Response File: Author Response.pdf
