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Pharmaceutics 2018, 10(3), 145; https://doi.org/10.3390/pharmaceutics10030145

Magnetogels: Prospects and Main Challenges in Biomedical Applications

1
Centre of Physics (CFUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
2
Centre of Chemistry (CQ-UM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
*
Author to whom correspondence should be addressed.
Received: 1 August 2018 / Revised: 24 August 2018 / Accepted: 30 August 2018 / Published: 4 September 2018
(This article belongs to the Special Issue Nanotheranostics and Cancer: Where Are We Now?)
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Abstract

Drug delivery nanosystems have been thriving in recent years as a promising application in therapeutics, seeking to solve the lack of specificity of conventional chemotherapy targeting and add further features such as enhanced magnetic resonance imaging, biosensing and hyperthermia. The combination of magnetic nanoparticles and hydrogels introduces a new generation of nanosystems, the magnetogels, which combine the advantages of both nanomaterials, apart from showing interesting properties unobtainable when both systems are separated. The presence of magnetic nanoparticles allows the control and targeting of the nanosystem to a specific location by an externally applied magnetic field gradient. Moreover, the application of an alternating magnetic field (AMF) not only allows therapy through hyperthermia, but also enhances drug delivery and chemotherapeutic desired effects, which combined with the hydrogel specificity, confer a high therapeutic efficiency. Therefore, the present review summarizes the magnetogels properties and critically discusses their current and recent biomedical applications, apart from an outlook on future goals and perspectives. View Full-Text
Keywords: hydrogels; magnetic nanoparticles; magnetic hyperthermia; drug delivery; cancer therapy; biomedical applications hydrogels; magnetic nanoparticles; magnetic hyperthermia; drug delivery; cancer therapy; biomedical applications
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style

Veloso, S.R.S.; Ferreira, P.M.T.; Martins, J.A.; Coutinho, P.J.G.; Castanheira, E.M.S. Magnetogels: Prospects and Main Challenges in Biomedical Applications. Pharmaceutics 2018, 10, 145.

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