The Effects of Synthetically Modified Natural Compounds on ABC Transporters
AbstractMultidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug absorption and disposition, and overexpression of ABC transporters has been shown to attenuate cellular/tissue drug accumulation and thus increase MDR across a variety of cancers. Overcoming MDR is one desired approach to improving the survival rate of patients. To date, a number of modulators have been identified which block the function and/or decrease the expression of ABC transporters, thereby restoring the efficacy of a range of anticancer drugs. However, clinical MDR reversal agents have thus far proven ineffective and/or toxic. The need for new, effective, well-tolerated and nontoxic compounds has led to the development of natural compounds and their derivatives to ameliorate MDR. This review evaluates whether synthetically modifying natural compounds is a viable strategy to generate potent, nontoxic, ABC transporter inhibitors which may potentially reverse MDR. View Full-Text
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Dantzic, D.; Noel, P.; Merien, F.; Liu, D.-X.; Lu, J.; Han, H.; McKeage, M.J.; Li, Y. The Effects of Synthetically Modified Natural Compounds on ABC Transporters. Pharmaceutics 2018, 10, 127.
Dantzic D, Noel P, Merien F, Liu D-X, Lu J, Han H, McKeage MJ, Li Y. The Effects of Synthetically Modified Natural Compounds on ABC Transporters. Pharmaceutics. 2018; 10(3):127.Chicago/Turabian Style
Dantzic, Daniel; Noel, Pawan; Merien, Fabrice; Liu, Dong-Xu; Lu, Jun; Han, Haiyong; McKeage, Mark J.; Li, Yan. 2018. "The Effects of Synthetically Modified Natural Compounds on ABC Transporters." Pharmaceutics 10, no. 3: 127.
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