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Pharmaceutics 2018, 10(2), 70; https://doi.org/10.3390/pharmaceutics10020070

Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation

1
Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu 804-8550, Japan
2
Department of Neurosurgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan
3
Nikkiso Co., Ltd., Ebisu, Shibuya-ku, Tokyo 150-6022, Japan
*
Author to whom correspondence should be addressed.
Received: 28 February 2018 / Revised: 30 May 2018 / Accepted: 4 June 2018 / Published: 8 June 2018
(This article belongs to the Special Issue Chitosan Biomedical Applications: Opportunities and Challenges)
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Abstract

Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration using chitosan-siloxane hybrids after long-term implantation (two and three years). After implantation of the hybrids, the surrounding cells migrated and formed fibrous tissues and blood vessels. Then, bone formation occurred from the surrounding blood vessels. Addition of calcium ions and coating with hydroxyapatite improved bone regeneration. Finally, the regenerated tissue area became smaller than the initial hole, and some areas changed to completed bone tissues. View Full-Text
Keywords: skull bone regeneration; chitosan-siloxane porous hybrid; long-term implantation skull bone regeneration; chitosan-siloxane porous hybrid; long-term implantation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Shirosaki, Y.; Furuse, M.; Asano, T.; Kinoshita, Y.; Kuroiwa, T. Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation. Pharmaceutics 2018, 10, 70.

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