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Pharmaceutics 2018, 10(1), 15; https://doi.org/10.3390/pharmaceutics10010015

Chitosan Gel to Treat Pressure Ulcers: A Clinical Pilot Study

1
Department of Pharmacy, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy
2
M.D. Department of Plastic and Reconstructive Surgery and Burn Unit, Hospital Hospital “A. Cardarelli”, Via A. Cardarelli 9, 80131 Naples, Italy
3
First Division of Nephrology, Department of Cardio-thoracic and Respiratory Sciences, Second University of Naples, School of Medicine, via Pansini 5, Ed. 17, 80131 Naples, Italy
4
U.O.S.C Farmacia, U.O.S.S. Galenica Clinica e Preparazione Farmaci Antiblastici, Hospital “A. Cardarelli”, Via A. Cardarelli 9, 80131 Naples, Italy
5
U.M.R.S. 1138, Centre de Recherche des Cordeliers, 15, rue de l’Ecole de Médecine, 75006 Paris, France
*
Author to whom correspondence should be addressed.
Received: 7 December 2017 / Revised: 10 January 2018 / Accepted: 14 January 2018 / Published: 17 January 2018
(This article belongs to the Special Issue Chitosan Biomedical Applications: Opportunities and Challenges)
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Abstract

Chitosan is biopolymer with promising properties in wound healing. Chronic wounds represent a significant burden to both the patient and the medical system. Among chronic wounds, pressure ulcers are one of the most common types of complex wound. The efficacy and the tolerability of chitosan gel formulation, prepared into the hospital pharmacy, in the treatment of pressure ulcers of moderate severity were evaluated. The endpoint of this phase II study was the reduction of the area of the lesion by at least 20% after four weeks of treatment. Thus, 20 adult volunteers with pressure ulcers within predetermined parameters were involved in a 30 days study. Dressing change was performed twice a week at outpatient clinic upon chronic wounds management. In the 90% of patients involved in the study, the treatment was effective, with a reduction of the area of the lesion and wound healing progress. The study demonstrated the efficacy of the gel formulation for treatment of pressure ulcers, also providing a strong reduction of patient management costs. View Full-Text
Keywords: chitosan; gel; pressure ulcers; chronic wounds; wound healing; clinical study chitosan; gel; pressure ulcers; chronic wounds; wound healing; clinical study
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Campani, V.; Pagnozzi, E.; Mataro, I.; Mayol, L.; Perna, A.; D’Urso, F.; Carillo, A.; Cammarota, M.; Maiuri, M.C.; De Rosa, G. Chitosan Gel to Treat Pressure Ulcers: A Clinical Pilot Study. Pharmaceutics 2018, 10, 15.

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