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Open AccessFeature PaperCommunication
Materials 2016, 9(7), 560; doi:10.3390/ma9070560

Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering

1
Lehrstuhl Biomaterialien, Universität Bayreuth, Universitätsstraße 30, Bayreuth 95447, Germany
2
DWI Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, Aachen 52056, Germany
3
Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, Potsdam 14476, Germany
4
Physical Chemistry, Department of Chemistry, University of Konstanz, Universitätsstr. 10, Konstanz D-78457, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Marek M. Kowalczuk
Received: 1 March 2016 / Revised: 6 June 2016 / Accepted: 24 June 2016 / Published: 11 July 2016
(This article belongs to the Special Issue Biodegradable and Bio-Based Polymers)
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Abstract

Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering. View Full-Text
Keywords: spider silk; recombinant protein; biodegradable polymers; biomaterials; biomineralization; bone tissue engineering spider silk; recombinant protein; biodegradable polymers; biomaterials; biomineralization; bone tissue engineering
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Hardy, J.G.; Torres-Rendon, J.G.; Leal-Egaña, A.; Walther, A.; Schlaad, H.; Cölfen, H.; Scheibel, T.R. Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering. Materials 2016, 9, 560.

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