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Materials 2016, 9(5), 337; doi:10.3390/ma9050337

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

1
Department of Orthopaedics, Faculty of Medicine and Dentistry, Palacký University Olomouc, I. P. Pavlova 6, Olomouc 779 00, Czech Republic
2
Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc, Šlechtitelů 27, Olomouc 783 71, Czech Republic
3
Department of Immunology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, Olomouc 779 00, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Fernão D. Magalhães
Received: 31 March 2016 / Revised: 26 April 2016 / Accepted: 27 April 2016 / Published: 5 May 2016
(This article belongs to the Special Issue Self-Cleaning and Antimicrobial Surfaces)
View Full-Text   |   Download PDF [2973 KB, uploaded 5 May 2016]   |  

Abstract

Prosthetic joint infection (PJI) is a feared complication of total joint arthroplasty associated with increased morbidity and mortality. There is a growing body of evidence that bacterial colonization and biofilm formation are critical pathogenic events in PJI. Thus, the choice of biomaterials for implanted prostheses and their surface modifications may significantly influence the development of PJI. Currently, silver nanoparticle (AgNP) technology is receiving much interest in the field of orthopaedics for its antimicrobial properties and a strong anti-biofilm potential. The great advantage of AgNP surface modification is a minimal release of active substances into the surrounding tissue and a long period of effectiveness. As a result, a controlled release of AgNPs could ensure antibacterial protection throughout the life of the implant. Moreover, the antibacterial effect of AgNPs may be strengthened in combination with conventional antibiotics and other antimicrobial agents. Here, our main attention is devoted to general guidelines for the design of antibacterial biomaterials protected by AgNPs, its benefits, side effects and future perspectives in PJI prevention. View Full-Text
Keywords: prosthetic joint infection; biomaterial-associated infection; anti-adhesive; anti-biofilm; antibacterial surface treatment; silver nanocoating; silver nanoparticles prosthetic joint infection; biomaterial-associated infection; anti-adhesive; anti-biofilm; antibacterial surface treatment; silver nanocoating; silver nanoparticles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gallo, J.; Panacek, A.; Prucek, R.; Kriegova, E.; Hradilova, S.; Hobza, M.; Holinka, M. Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection. Materials 2016, 9, 337.

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