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Materials 2016, 9(4), 259; doi:10.3390/ma9040259

Microparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects

1
Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisban, QLD 4006, Australia
2
Department of Trauma Surgery, University of Regensburg, Regensburg 93164, Germany
3
School of Pharmacy, University Park, The University of Nottingham, University Park, Nottingham NG7 2RD, UK
*
Author to whom correspondence should be addressed.
Academic Editor: C. Edi Tanase
Received: 18 January 2016 / Revised: 18 March 2016 / Accepted: 18 March 2016 / Published: 31 March 2016
(This article belongs to the Special Issue Regenerative Materials)
View Full-Text   |   Download PDF [3208 KB, uploaded 31 March 2016]   |  

Abstract

This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a large segmental bone defect model. We hypothesised that co-delivery of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) followed by bone morphogenetic protein-2 (BMP-2) could be more effective in stimulating bone repair than the delivery of BMP-2 alone. Poly(lactic-co-glycolic acid) (PLGA ) based microparticles were used as a delivery system to achieve a controlled release of growth factors within a medical-grade Polycaprolactone (PCL) scaffold. The scaffolds were assessed in a well-established preclinical ovine tibial segmental defect measuring 3 cm. After six months, mechanical properties and bone tissue regeneration were assessed. Mineralised bone bridging of the defect was enhanced in growth factor treated groups. The inclusion of VEGF and PDGF (with BMP-2) had no significant effect on the amount of bone regeneration at the six-month time point in comparison to BMP-2 alone. However, regions treated with VEGF and PDGF showed increased vascularity. This study demonstrates an effective method for the controlled delivery of therapeutic growth factors in vivo, using microparticles. View Full-Text
Keywords: growth factor; scaffold; bone; repair; regeneration; microparticle; segmental defect growth factor; scaffold; bone; repair; regeneration; microparticle; segmental defect
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kirby, G.T.S.; White, L.J.; Steck, R.; Berner, A.; Bogoevski, K.; Qutachi, O.; Jones, B.; Saifzadeh, S.; Hutmacher, D.W.; Shakesheff, K.M.; Woodruff, M.A. Microparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects. Materials 2016, 9, 259.

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