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Materials 2016, 9(3), 175;

Preparation and Evaluation of Dexamethasone-Loaded Electrospun Nanofiber Sheets as a Sustained Drug Delivery System

Department of Applied Chemistry and Biological Engineering, Ajou University, Suwon 443-759, Korea
Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Nicole Zander and Franz E. Weber
Received: 29 December 2015 / Revised: 31 January 2016 / Accepted: 1 March 2016 / Published: 8 March 2016
(This article belongs to the Special Issue Electrospun Materials)
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Recently, electrospinning technology has been widely used as a processing method to make nanofiber sheets (NS) for biomedical applications because of its unique features, such as ease of fabrication and high surface area. To develop a sustained dexamethasone (Dex) delivery system, in this work, poly(ε-caprolactone-co-l-lactide) (PCLA) copolymer with controllable biodegradability was synthesized and further utilized to prepare electrospun Dex-loaded NS using water-insoluble Dex (Dex(b)) or water-soluble Dex (Dex(s)). The Dex-NS obtained by electrospinning exhibited randomly oriented and interconnected fibrillar structures. The in vitro and in vivo degradation of Dex-NS was confirmed over a period of a few weeks by gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR). The evaluation of in vitro and in vivo Dex(b) and Dex(s) release from Dex-NS showed an initial burst of Dex(b) at day 1 and, thereafter, almost the same amount of release as Dex(b) for up to 28 days. In contrast, Dex(s)-NS exhibited a small initial burst of Dex(s) and a first-order releasing profile from Dex-NS. In conclusion, Dex-NS exhibited sustained in vitro and in vivo Dex(s) release for a prolonged period, as well as controlled biodegradation of the NS over a defined treatment period. View Full-Text
Keywords: electrospinning; nanofiber sheets; dexamethasone; sustained delivery; biodegradation electrospinning; nanofiber sheets; dexamethasone; sustained delivery; biodegradation

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Lee, J.W.; Lee, H.Y.; Park, S.H.; Park, J.H.; Kim, J.H.; Min, B.H.; Kim, M.S. Preparation and Evaluation of Dexamethasone-Loaded Electrospun Nanofiber Sheets as a Sustained Drug Delivery System. Materials 2016, 9, 175.

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