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Materials 2016, 9(3), 175; doi:10.3390/ma9030175

Preparation and Evaluation of Dexamethasone-Loaded Electrospun Nanofiber Sheets as a Sustained Drug Delivery System

1
Department of Applied Chemistry and Biological Engineering, Ajou University, Suwon 443-759, Korea
2
Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Nicole Zander and Franz E. Weber
Received: 29 December 2015 / Revised: 31 January 2016 / Accepted: 1 March 2016 / Published: 8 March 2016
(This article belongs to the Special Issue Electrospun Materials)
View Full-Text   |   Download PDF [3787 KB, uploaded 8 March 2016]   |  

Abstract

Recently, electrospinning technology has been widely used as a processing method to make nanofiber sheets (NS) for biomedical applications because of its unique features, such as ease of fabrication and high surface area. To develop a sustained dexamethasone (Dex) delivery system, in this work, poly(ε-caprolactone-co-l-lactide) (PCLA) copolymer with controllable biodegradability was synthesized and further utilized to prepare electrospun Dex-loaded NS using water-insoluble Dex (Dex(b)) or water-soluble Dex (Dex(s)). The Dex-NS obtained by electrospinning exhibited randomly oriented and interconnected fibrillar structures. The in vitro and in vivo degradation of Dex-NS was confirmed over a period of a few weeks by gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR). The evaluation of in vitro and in vivo Dex(b) and Dex(s) release from Dex-NS showed an initial burst of Dex(b) at day 1 and, thereafter, almost the same amount of release as Dex(b) for up to 28 days. In contrast, Dex(s)-NS exhibited a small initial burst of Dex(s) and a first-order releasing profile from Dex-NS. In conclusion, Dex-NS exhibited sustained in vitro and in vivo Dex(s) release for a prolonged period, as well as controlled biodegradation of the NS over a defined treatment period. View Full-Text
Keywords: electrospinning; nanofiber sheets; dexamethasone; sustained delivery; biodegradation electrospinning; nanofiber sheets; dexamethasone; sustained delivery; biodegradation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, J.W.; Lee, H.Y.; Park, S.H.; Park, J.H.; Kim, J.H.; Min, B.H.; Kim, M.S. Preparation and Evaluation of Dexamethasone-Loaded Electrospun Nanofiber Sheets as a Sustained Drug Delivery System. Materials 2016, 9, 175.

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